Phenotypes associated with this allele

• Allele Symbol: Tmem219^{tm1(KOMP)Vlcg}
• Allele Name: targeted mutation 1, Velocigene
• Allele ID: MGI:4399704
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmem219^tm1(KOMP)Vlcg/Tmem219^tm1(KOMP)Vlcg	B6J.B6N-Tmem219^tm1(KOMP)Vlcg	MGI:5903459
cx2	Tmem219^tm1(KOMP)Vlcg/Tmem219^tm1(KOMP)Vlcg Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0	involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA	MGI:5903460

Genotype
MGI:5903459

hm1

• Allelic Composition: Tmem219^{tm1(KOMP)Vlcg}/Tmem219^{tm1(KOMP)Vlcg}
• Genetic Background: B6J.B6N-Tmem219^{tm1(KOMP)Vlcg}
• Cell Lines: 13990A-E6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

abnormal susceptibility to injury induced morbidity/mortality ( J:236976 )

• increased following exposure to 100% oxygen

immune system

immune system phenotype ( J:236976 )

N • following ovalbumin sensitization and challenge, bronchoalveolar lavage fluid levels of IL1beta are normal

increased eosinophil cell number ( J:236976 )

• in bronchoalveolar lavage fluid following ovalbumin sensitization and challenge

increased IgE level ( J:236976 )

• ovalbumin-specific IgE in bronchoalveolar lavage fluid following ovalbumin sensitization and challenge

increased interleukin-13 secretion ( J:236976 )

• in bronchoalveolar lavage fluid following ovalbumin sensitization and challenge

increased interleukin-4 secretion ( J:236976 )

• in bronchoalveolar lavage fluid following ovalbumin sensitization and challenge

respiratory system

increased lung apoptosis ( J:236976 )

• mice exposed to 100% oxygen exhibit exaggerated lung apoptosis in airway and parenchymal epithelial cells compared with wild-type mice

neoplasm

decreased metastatic potential ( J:236976 )

• reduced lung metastasis of transplanted B16-F10 melanoma cells

cellular

increased lung apoptosis ( J:236976 )

• mice exposed to 100% oxygen exhibit exaggerated lung apoptosis in airway and parenchymal epithelial cells compared with wild-type mice

hematopoietic system

increased eosinophil cell number ( J:236976 )

• in bronchoalveolar lavage fluid following ovalbumin sensitization and challenge

increased IgE level ( J:236976 )

• ovalbumin-specific IgE in bronchoalveolar lavage fluid following ovalbumin sensitization and challenge

homeostasis/metabolism

decreased transforming growth factor beta level ( J:236976 )

• in bronchoalveolar lavage fluid of mice receiving B16-F10 melanoma cells

abnormal susceptibility to injury induced morbidity/mortality ( J:236976 )

• increased following exposure to 100% oxygen

increased susceptibility to injury ( J:236976 )

• mice exposed to 100% oxygen exhibit exaggerated lung apoptosis in airway and parenchymal epithelial cells with increased bronchoalveolar total protein and decreased survival compared with wild-type mice

Genotype
MGI:5903460

cx2

• Allelic Composition: Tmem219^{tm1(KOMP)Vlcg}/Tmem219^{tm1(KOMP)Vlcg}; Tg(Scgb1a1-rtTA,tetO-Il13)1Eli/0
• Genetic Background: involves: C57BL/6 * C57BL/6J * C57BL/6N * CBA
• Cell Lines: 13990A-E6

respiratory system

lung inflammation ( J:236976 )

• increased inflammation, mucus metaplasia and bronchoalveolar lavage fluid in mice sensitized and challenged with ovalbumin

pulmonary fibrosis ( J:236976 )

• in mice sensitized and challenged with ovalbumin

immune system

lung inflammation ( J:236976 )

• increased inflammation, mucus metaplasia and bronchoalveolar lavage fluid in mice sensitized and challenged with ovalbumin

homeostasis/metabolism

increased transforming growth factor beta level ( J:236976 )

• increased total and active TGFB1 in the lungs in mice sensitized and challenged with ovalbumin