All Phenotypes Eomes<tm2.1Rob> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Eomes^tm2.1Rob
targeted mutation 2.1, Elizabeth J Robertson
MGI:4399131

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eomes^tm2.1Rob/Eomes^tm2.1Rob	involves: 129S/SvEv * C57BL/6	MGI:4399136
cn2	Eomes^tm1Rob/Eomes^tm2.1Rob Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129S/SvEv * C57BL/6 * CBA	MGI:4399139

Allelic Composition	Eomes^tm2.1Rob/Eomes^tm2.1Rob
Genetic Background	involves: 129S/SvEv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eomes^tm2.1Rob mutation (0 available); any Eomes mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:154785 )

• mice die prior to E7.5

Allelic Composition	Eomes^tm1Rob/Eomes^tm2.1Rob Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129S/SvEv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (42 available)
Eomes^tm1Rob mutation (0 available); any Eomes mutation (41 available)
Eomes^tm2.1Rob mutation (0 available); any Eomes mutation (41 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Eomes^tm1Rob/Eomes^tm2.1Rob Edil3^{Tg(Sox2-cre)1Amc}/0 embryos fail to form the mesoderm cell layer and are blocked in gastrulation

embryo

failure to gastrulate ( J:154785 )

• mice are blocked in gastrulation

abnormal embryonic epiblast morphology ( J:154785 )

• epiblast cells fails to undergo the epithelial to mesenchyme transition and to form a distinctive mesodermal cell layer unlike in wild-type mice

abnormal primitive streak morphology ( J:154785 )

• unlike in wild-type mice, the primitive streak is populated by nascent mesoderm

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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