Phenotypes associated with this allele

• Allele Symbol: Eomes^tm2.1Rob
• Allele Name: targeted mutation 2.1, Elizabeth J Robertson
• Allele ID: MGI:4399131
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Eomes^tm2.1Rob/Eomes^tm2.1Rob	involves: 129S/SvEv * C57BL/6	MGI:4399136
cn2	Eomes^tm1Rob/Eomes^tm2.1Rob Edil3^Tg(Sox2-cre)1Amc/Edil3^+	involves: 129S/SvEv * C57BL/6 * CBA	MGI:4399139

Genotype
MGI:4399136

hm1

• Allelic Composition: Eomes^tm2.1Rob/Eomes^tm2.1Rob
• Genetic Background: involves: 129S/SvEv * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality between implantation and placentation, complete penetrance ( J:154785 )

• mice die prior to E7.5

Genotype
MGI:4399139

cn2

• Allelic Composition: Eomes^tm1Rob/Eomes^tm2.1Rob; Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
• Genetic Background: involves: 129S/SvEv * C57BL/6 * CBA

Eomes^tm1Rob/Eomes^tm2.1Rob Edil3^{Tg(Sox2-cre)1Amc}/0 embryos fail to form the mesoderm cell layer and are blocked in gastrulation

embryo

failure to gastrulate ( J:154785 )

• mice are blocked in gastrulation

abnormal embryonic epiblast morphology ( J:154785 )

• epiblast cells fails to undergo the epithelial to mesenchyme transition and to form a distinctive mesodermal cell layer unlike in wild-type mice

abnormal primitive streak morphology ( J:154785 )

• unlike in wild-type mice, the primitive streak is populated by nascent mesoderm