All Phenotypes Wnt4<tm2(EGFP/cre)Svo> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Wnt4^{tm2(EGFP/cre)Svo}
targeted mutation 2, Seppo Vainio
MGI:4399121

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Wnt4^{tm2(EGFP/cre)Svo}/Wnt4^tm1Svo	involves: 129/Sv * C57BL/6	MGI:4399126
cn2	Hnf1b^tm1Ics/Hnf1b⁺ Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺	involves: 129P2/OlaHsd	MGI:5471841
cn3	Hnf1b^tm1Sce/Hnf1b⁺ Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺	involves: 129P2/OlaHsd	MGI:5471842
cn4	Hnf1b^tm1Ics/Hnf1b^tm1Sce Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺	involves: 129P2/OlaHsd	MGI:5471840
cn5	Dkk1^tm1.1Svo/Dkk1^tm1.2Svo Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺	involves: 129P2/OlaHsd * C57BL/6 * SJL	MGI:5013425
cn6	Tcf21^tm2.1Seq/Tcf21^tm1Jrt Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺	involves: 129S1/Sv * 129X1/SvJ	MGI:5613386

Allelic Composition	Wnt4^{tm2(EGFP/cre)Svo}/Wnt4^tm1Svo
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Wnt4^tm1Svo mutation (0 available); any Wnt4 mutation (20 available)
Wnt4^{tm2(EGFP/cre)Svo} mutation (1 available); any Wnt4 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

Severe anomalies in the urogenital system in Wnt4^{tm2(EGFP/cre)Svo}/Wnt4^tm1Svo mice

renal/urinary system

abnormal kidney development ( J:154784 )

• some mice exhibit occasional glomerula and nephron structures

abnormal kidney mesenchyme morphology ( J:154784 )

• mesenchyme in the developing kidney remains undifferentiated compared to in wild-type mice

small kidney ( J:154784 )

• at E18.5

absent kidney ( J:154784 )

reproductive system

absent ovary capsule ( J:154784 )

• ovaries remain are not encapsulated

abnormal ovary development ( J:154784 )

• ovaries remain round and are not encapsulated unlike in wild-type mice

primary sex reversal ( J:154784 )

• female mice exhibit partial sex reversal with persistent Wolffian duct and failure of Mullerian duct development unlike in wild-type mice

endocrine/exocrine glands

absent ovary capsule ( J:154784 )

• ovaries remain are not encapsulated

abnormal ovary development ( J:154784 )

• ovaries remain round and are not encapsulated unlike in wild-type mice

Allelic Composition	Hnf1b^tm1Ics/Hnf1b⁺ Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hnf1b^tm1Ics mutation (0 available); any Hnf1b mutation (16 available)
Wnt4^{tm2(EGFP/cre)Svo} mutation (1 available); any Wnt4 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal glomerulus cyst ( J:194051 )

• in some mice

abnormal renal tubule morphology ( J:194051 )

• enlarged, more obvious at E15.5 than at P0

growth/size/body

renal glomerulus cyst ( J:194051 )

• in some mice

Allelic Composition	Hnf1b^tm1Sce/Hnf1b⁺ Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hnf1b^tm1Sce mutation (2 available); any Hnf1b mutation (16 available)
Wnt4^{tm2(EGFP/cre)Svo} mutation (1 available); any Wnt4 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:194051 )

N	• glomerular cysts and enlarged tubules are not seen, unlike in mice heterozygous for Hnf1b^tm1Ics and Wnt4^{tm2(EGFP/cre)Svo}

Allelic Composition	Hnf1b^tm1Ics/Hnf1b^tm1Sce Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺
Genetic Background	involves: 129P2/OlaHsd

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hnf1b^tm1Ics mutation (0 available); any Hnf1b mutation (16 available)
Hnf1b^tm1Sce mutation (2 available); any Hnf1b mutation (16 available)
Wnt4^{tm2(EGFP/cre)Svo} mutation (1 available); any Wnt4 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:194051 )

• die within the first 2 days after birth

renal/urinary system

abnormal kidney morphology ( J:194051 )

• higher density of mature glomeruli in the medulla region compared to the periphery unlike in controls

renal glomerulus cyst ( J:194051 )

• 12-16% of glomeruli become cystic

abnormal metanephros morphology ( J:194051 )

• expression analysis indicates a defect in proximal and intermediate regions of the S-shaped bodies development during tubule development

• S-shaped bodies appear less convoluted

• decrease in proliferation in comma-shaped bodies and a stronger decrease in the future proximal tubule of S-shaped bodies at E16.5

• increase in apoptosis in kidney epithelium but not stroma at E16.5

• strong increase in apoptosis in late mutant nephron tubules and a more moderate increase in S-shaped bodies

hydronephrosis ( J:194051 )

• occasional

abnormal renal tubule morphology ( J:194051 )

• decrease in tubular structures

• reduction of 43.5% in mature glomeruli mutant kidneys

• higher density of mature glomeruli in the medulla region compared to the periphery unlike in controls

abnormal loop of Henle morphology ( J:194051 )

• medullar elongated loop of Henle tubules are not visible at P0

abnormal proximal convoluted tubule morphology ( J:194051 )

• not visible at P0

growth/size/body

renal glomerulus cyst ( J:194051 )

• 12-16% of glomeruli become cystic

Allelic Composition	Dkk1^tm1.1Svo/Dkk1^tm1.2Svo Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dkk1^tm1.1Svo mutation (1 available); any Dkk1 mutation (17 available)
Dkk1^tm1.2Svo mutation (0 available); any Dkk1 mutation (17 available)
Wnt4^{tm2(EGFP/cre)Svo} mutation (1 available); any Wnt4 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

renal/urinary system phenotype ( J:173125 )

N	• mice exhibit normal kidneys

Allelic Composition	Tcf21^tm2.1Seq/Tcf21^tm1Jrt Wnt4^{tm2(EGFP/cre)Svo}/Wnt4⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf21^tm1Jrt mutation (0 available); any Tcf21 mutation (14 available)
Tcf21^tm2.1Seq mutation (0 available); any Tcf21 mutation (14 available)
Wnt4^{tm2(EGFP/cre)Svo} mutation (1 available); any Wnt4 mutation (20 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

renal/urinary system

abnormal podocyte morphology ( J:217144 )

• defective foot process formation

• podocytes remain columnar at E18.5

abnormal renal glomerulus morphology ( J:217144 )

• glomeruli are primitive and reduced in size at E18.5

• complexity of glomerulus is reduced

small kidney ( J:217144 )

• slightly reduced in size but no overt abnormality in tubular formation

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23