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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Meioctm1a(KOMP)Wtsi
targeted mutation 1a, Wellcome Trust Sanger Institute
MGI:4362869
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Meioctm1a(KOMP)Wtsi/Meioctm1a(KOMP)Wtsi involves: C57BL/6 * C57BL/6N * NMRI MGI:5897825
cx2
 		Meioctm1a(KOMP)Wtsi/Meioctm1a(KOMP)Wtsi
Spo11tm1Mjn/Spo11tm1Mjn 		involves: 129X1/SvJ * C57BL/6N MGI:5897826


Genotype
MGI:5897825
hm1
Allelic
Composition		 Meioctm1a(KOMP)Wtsi/Meioctm1a(KOMP)Wtsi
Genetic
Background		 involves: C57BL/6 * C57BL/6N * NMRI
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meioctm1a(KOMP)Wtsi mutation (0 available); any Meioc mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
decreased oocyte number ( J:231231 )
• in the perinatal period
absent oocytes ( J:231231 )
• at early as P8
decreased male germ cell number ( J:231231 )
• 60% of tubules contain spermatocytes arrested in early meiosis prophase I (preleptotene, leptotene and zygotene) and remaining tubules have only spermatogonia
azoospermia ( J:231231 )
• absence of spermatozoon in the seminiferous tubules and epididymides
arrest of male meiosis ( J:231231 )
• 60% of tubules contain spermatocytes arrested in early meiosis prophase I (preleptotene, leptotene and zygotene) and remaining tubules have only spermatogonia
small ovary ( J:231231 )
• barely detectible
small testis ( J:231231 )
• barely detectible

homeostasis/metabolism

cellular
decreased oocyte number ( J:231231 )
• in the perinatal period
absent oocytes ( J:231231 )
• at early as P8
decreased male germ cell number ( J:231231 )
• 60% of tubules contain spermatocytes arrested in early meiosis prophase I (preleptotene, leptotene and zygotene) and remaining tubules have only spermatogonia
azoospermia ( J:231231 )
• absence of spermatozoon in the seminiferous tubules and epididymides
arrest of male meiosis ( J:231231 )
• 60% of tubules contain spermatocytes arrested in early meiosis prophase I (preleptotene, leptotene and zygotene) and remaining tubules have only spermatogonia

endocrine/exocrine glands
small ovary ( J:231231 )
• barely detectible
small testis ( J:231231 )
• barely detectible




Genotype
MGI:5897826
cx2
Allelic
Composition		 Meioctm1a(KOMP)Wtsi/Meioctm1a(KOMP)Wtsi
Spo11tm1Mjn/Spo11tm1Mjn
Genetic
Background		 involves: 129X1/SvJ * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Meioctm1a(KOMP)Wtsi mutation (0 available); any Meioc mutation (38 available)
Spo11tm1Mjn mutation (2 available); any Spo11 mutation (20 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
arrest of male meiosis ( J:231231 )
• in early meiosis prophase I

cellular
arrest of male meiosis ( J:231231 )
• in early meiosis prophase I




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory