Phenotypes associated with this allele

• Allele Symbol: Tg(Krt19-Wnt1)2Maos
• Allele Name: transgene insertion 2, Masanobu Oshima
• Allele ID: MGI:4361187
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Gins4^tm1Ntak/Gins4^+ Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0 Tg(Krt19-Wnt1)2Maos/0	involves: 129P2/OlaHsd * C3H * C57BL/6	MGI:5575638
cx2	Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0 Tg(Krt19-Wnt1)2Maos/0	involves: C3H * C57BL/6	MGI:4361196
cx3	Hmga1^tm1Mina/Hmga1^tm1Mina Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0 Tg(Krt19-Wnt1)2Maos/0	involves: C3H * C57BL/6 * CBA	MGI:4361195
tg4	Tg(Krt19-Wnt1)2Maos/0	involves: C3H * C57BL/6	MGI:4946087

Genotype
MGI:5575638

cx1

• Allelic Composition: Gins4^tm1Ntak/Gins4⁺; Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0; Tg(Krt19-Wnt1)2Maos/0
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

decreased tumor growth/size ( J:209708 )

• as measured by weight of the stomachs and tumor

Genotype
MGI:4361196

cx2

• Allelic Composition: Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0; Tg(Krt19-Wnt1)2Maos/0
• Genetic Background: involves: C3H * C57BL/6

mortality/aging

decreased tumor-free survival time ( J:116782 )

• some mice die between 25 and 50 weeks of age due to tumors

neoplasm

increased stomach tumor incidence ( J:116782 , J:153058 )

• 100% penetrance of dysplastic gastric tumors in mice older than 20 weeks of age, with tumors consisting of dysplastic epithelial cells with nuclear stratification and irregularly branched tubules (J:116782)

• tumors resemble human intestinal-type gastric cancer and gastric adenocarcinoma (J:116782)

• tumor invasion into the smooth muscle layers is seen in 50%, 75% and 100% of mutants at 20, 30, and 50 weeks of age, respectively (J:116782)

• tumors exhibit an accumulation of macrophages and increased angiogenesis (J:116782)

increased gastric adenocarcinoma incidence ( J:116782 )

digestive/alimentary system

abnormal stomach glandular epithelium morphology ( J:116782 )

• hyperproliferation of gastric epithelial cells

gastric metaplasia ( J:116782 )

• mutants exhibit mucous metaplasia as early as 5 weeks of age, before dysplastic tumor formation

increased stomach tumor incidence ( J:116782 , J:153058 )

• 100% penetrance of dysplastic gastric tumors in mice older than 20 weeks of age, with tumors consisting of dysplastic epithelial cells with nuclear stratification and irregularly branched tubules (J:116782)

• tumors resemble human intestinal-type gastric cancer and gastric adenocarcinoma (J:116782)

• tumor invasion into the smooth muscle layers is seen in 50%, 75% and 100% of mutants at 20, 30, and 50 weeks of age, respectively (J:116782)

• tumors exhibit an accumulation of macrophages and increased angiogenesis (J:116782)

increased gastric adenocarcinoma incidence ( J:116782 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
stomach cancer		DOID:10534	OMIM:613659	J:116782

Genotype
MGI:4361195

cx3

• Allelic Composition: Hmga1^tm1Mina/Hmga1^tm1Mina; Tg(Krt19-Ptgs2,Krt19-Ptges)8Tko/0; Tg(Krt19-Wnt1)2Maos/0
• Genetic Background: involves: C3H * C57BL/6 * CBA

neoplasm

increased stomach tumor incidence ( J:153058 )

digestive/alimentary system

increased stomach tumor incidence ( J:153058 )

Genotype
MGI:4946087

tg4

• Allelic Composition: Tg(Krt19-Wnt1)2Maos/0
• Genetic Background: involves: C3H * C57BL/6

digestive/alimentary system

abnormal stomach glandular region morphology ( J:116782 )

• mutants develop small preneoplastic lesions in the glandular stomach consisting of undifferentiated epithelial cells with macrophage accumulation

abnormal stomach glandular epithelium morphology ( J:116782 )

• marker analysis indicates expansion of the undifferentiated progenitor cell population in the grandular stomach and suppression of gastric epithelial differentiation