Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Wnk1)Clhu mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Kdrtm1(cre)Sato mutation
(1 available);
any
Kdr mutation
(71 available)
Wnk1Gt(OST38262)Lex mutation
(1 available);
any
Wnk1 mutation
(113 available)
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cardiovascular system
N |
• unlike single Wnk1 homozygotes, heart morphology is grossly normal
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embryo
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• the incidence of abnormal embryos is increased compared to controls indicating only a partial rescue
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Wnk1)Clhu mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Tg(Tek-cre)12Flv mutation
(1 available)
Wnk1Gt(OST38262)Lex mutation
(1 available);
any
Wnk1 mutation
(113 available)
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mortality/aging
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• all but one, died within 1 day of birth
• however, the early lethality seen in single Wnk1 homozygotes does not occur
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cardiovascular system
N |
• unlike single Wnk1 homozygotes, heart morphology is grossly normal at E15.5
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embryo
|
• the incidence of abnormal embryos is increased compared to controls indicating only a partial rescue
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3Tg(Sox2-cre)1Amc mutation
(5 available);
any
Edil3 mutation
(42 available)
Gt(ROSA)26Sortm1(Wnk1)Clhu mutation
(0 available);
any
Gt(ROSA)26Sor mutation
(944 available)
Wnk1Gt(OST38262)Lex mutation
(1 available);
any
Wnk1 mutation
(113 available)
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mortality/aging
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• expression of Wnk1 in the somatic embryonic cells fails to rescue the phenotypes seen in Wnk1 null embryos
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