reproductive system
N |
• unlike males, females are fully fertile
(J:165087)
|
N |
• adult males show a normal number of Sertoli cells in the seminiferous tubules with no apparent defect in their position, cell volume or morphology
(J:165087)
|
|
• in adult testes, the number of undifferentiated spermatogonial cells is significantly reduced, as determined by TRA98 staining
• however, the number of TRA98-positive cells at P5 is normal, indicating normal primordial germ cell (PGC) migration during embryogenesis
|
|
• adult mice show a significant loss of TRA98-positive spermatogenic cells with no detectable changes in the numbers of PLZF-positive spermatogonial stem cells (SSCs)
• adult testes show loss of c-Kit-positive type B spermatogonia and spermatocytes
|
|
• at P10, TUNEL staining showed a 2.5-fold increase in apoptosis within the seminiferous tubules, whereas only a few TUNEL-positive cells are detected in wild-type testes
|
|
• a paucity of cells is observed within seminiferous tubules
|
|
• focal hyperplasia of the testis interstitial components is observed
• however, Leydig cell number is normal
|
|
• males exhibit severe testicular hypotrophy at 24 weeks of age
|
|
• average testis weight is significantly decreased at 24 weeks of age
|
|
• spermatogenesis is severely impaired
|
|
• decrease in number of spermatozoa ranges from oligozoospermia to azoospermia
|
|
• number of spermatozoa obtained from the deferens ducts is significantly decreased
• decrease in number of spermatozoa ranges from oligozoospermia to azoospermia
|
|
• number of actively proliferating PCNA and cyclin D1-positive cells is strikingly reduced at P10 and at 8 weeks of age
|
|
• when males are mated with receptive females for 6 months, the number of litters produced per month is significantly lower than that for wild-type males
|
cellular
|
• in adult testes, the number of undifferentiated spermatogonial cells is significantly reduced, as determined by TRA98 staining
• however, the number of TRA98-positive cells at P5 is normal, indicating normal primordial germ cell (PGC) migration during embryogenesis
|
|
• adult mice show a significant loss of TRA98-positive spermatogenic cells with no detectable changes in the numbers of PLZF-positive spermatogonial stem cells (SSCs)
• adult testes show loss of c-Kit-positive type B spermatogonia and spermatocytes
|
|
• decrease in number of spermatozoa ranges from oligozoospermia to azoospermia
|
|
• number of spermatozoa obtained from the deferens ducts is significantly decreased
• decrease in number of spermatozoa ranges from oligozoospermia to azoospermia
|
|
• at P10, TUNEL staining showed a 2.5-fold increase in apoptosis within the seminiferous tubules, whereas only a few TUNEL-positive cells are detected in wild-type testes
|
|
• number of actively proliferating PCNA and cyclin D1-positive cells is strikingly reduced at P10 and at 8 weeks of age
|
homeostasis/metabolism
endocrine/exocrine glands
|
• at P10, TUNEL staining showed a 2.5-fold increase in apoptosis within the seminiferous tubules, whereas only a few TUNEL-positive cells are detected in wild-type testes
|
|
• a paucity of cells is observed within seminiferous tubules
|
|
• focal hyperplasia of the testis interstitial components is observed
• however, Leydig cell number is normal
|
|
• males exhibit severe testicular hypotrophy at 24 weeks of age
|
|
• average testis weight is significantly decreased at 24 weeks of age
|