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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Sox17tm1Jaw
targeted mutation 1, Jeffrey A Whitsett
MGI:4356113
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Sox17tm1Jaw/Sox17tm1Sjm
Tg(Foxa3-cre)1Khk/0 		involves: 129 * C57BL/6 * DBA MGI:4356148
cn2
 		Sox17tm1Jaw/Sox17tm1Sjm
Tg(Pdx1-cre)6Tuv/0 		involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB/N MGI:4356150
cn3
 		Sox17tm1Jaw/Sox17tm1Jaw
Tg(Foxa3-cre)1Khk/0 		involves: 129S6/SvEvTac * C57BL/6 * DBA MGI:4356147
cn4
 		Sox17tm1Jaw/Sox17tm1Jaw
Tg(Pdx1-cre)6Tuv/0 		involves: 129S6/SvEvTac * FVB/N MGI:4356152


Genotype
MGI:4356148
cn1
Allelic
Composition		 Sox17tm1Jaw/Sox17tm1Sjm
Tg(Foxa3-cre)1Khk/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox17tm1Jaw mutation (1 available); any Sox17 mutation (28 available)
Sox17tm1Sjm mutation (1 available); any Sox17 mutation (28 available)
Tg(Foxa3-cre)1Khk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal bile duct development ( J:151981 )
• at E9.5, Ipfl (Pdx1)+ cells are found throughout the liver bud unlike in control mice
• at E10.5, the biliary/gall bladder primordium is absent unlike in control mice
• however, cell proliferation and apoptosis rates are normal

liver/biliary system
abnormal bile duct development ( J:151981 )
• at E9.5, Ipfl (Pdx1)+ cells are found throughout the liver bud unlike in control mice
• at E10.5, the biliary/gall bladder primordium is absent unlike in control mice
• however, cell proliferation and apoptosis rates are normal




Genotype
MGI:4356150
cn2
Allelic
Composition		 Sox17tm1Jaw/Sox17tm1Sjm
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * 129X1/SvJ * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox17tm1Jaw mutation (1 available); any Sox17 mutation (28 available)
Sox17tm1Sjm mutation (1 available); any Sox17 mutation (28 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal bile duct development ( J:151981 )
• at E9.5, Ipfl (Pdx1)+ cells are found throughout the liver bud unlike in control mice
• at E10.0, the biliary primordium is absent unlike in control mice
absent gallbladder ( J:151981 )
• at E16.5

liver/biliary system
abnormal bile duct development ( J:151981 )
• at E9.5, Ipfl (Pdx1)+ cells are found throughout the liver bud unlike in control mice
• at E10.0, the biliary primordium is absent unlike in control mice
absent gallbladder ( J:151981 )
• at E16.5




Genotype
MGI:4356147
cn3
Allelic
Composition		 Sox17tm1Jaw/Sox17tm1Jaw
Tg(Foxa3-cre)1Khk/0
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox17tm1Jaw mutation (1 available); any Sox17 mutation (28 available)
Tg(Foxa3-cre)1Khk mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal bile duct development ( J:151981 )
• at E9.5, Ipfl (Pdx1)+ cells are found throughout the liver bud unlike in control mice
• at E10.5, the biliary/gall bladder primordium is absent unlike in control mice
• however, cell proliferation and apoptosis rates are normal
abnormal common bile duct morphology ( J:151981 )
• at E16.5, 50% of mice exhibit ectopic pancreatic tissue in the common duct unlike control mice
absent gallbladder ( J:151981 )
• at E16.5

liver/biliary system
abnormal bile duct development ( J:151981 )
• at E9.5, Ipfl (Pdx1)+ cells are found throughout the liver bud unlike in control mice
• at E10.5, the biliary/gall bladder primordium is absent unlike in control mice
• however, cell proliferation and apoptosis rates are normal
abnormal common bile duct morphology ( J:151981 )
• at E16.5, 50% of mice exhibit ectopic pancreatic tissue in the common duct unlike control mice
absent gallbladder ( J:151981 )
• at E16.5




Genotype
MGI:4356152
cn4
Allelic
Composition		 Sox17tm1Jaw/Sox17tm1Jaw
Tg(Pdx1-cre)6Tuv/0
Genetic
Background		 involves: 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Sox17tm1Jaw mutation (1 available); any Sox17 mutation (28 available)
Tg(Pdx1-cre)6Tuv mutation (3 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal bile duct development ( J:151981 )
• at E10.5, the biliary primordium is reduced compared to in control mice

liver/biliary system
abnormal bile duct development ( J:151981 )
• at E10.5, the biliary primordium is reduced compared to in control mice




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05/07/2024
MGI 6.23 		The Jackson Laboratory