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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rfktm1.1Jcbr
targeted mutation 1.1, Jens C Bruning
MGI:4356069
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
cn1
Rfktm1.1Jcbr/Rfktm1.1Jcbr
Tg(Mx1-cre)1Cgn/?
involves: C57BL/6 * CBA MGI:4356077


Genotype
MGI:4356077
cn1
Allelic
Composition
Rfktm1.1Jcbr/Rfktm1.1Jcbr
Tg(Mx1-cre)1Cgn/?
Genetic
Background
involves: C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rfktm1.1Jcbr mutation (0 available); any Rfk mutation (19 available)
Tg(Mx1-cre)1Cgn mutation (7 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• macrophges from mice where cre recombinase expression was induced produce less reactive NO in response to IFN-gamma, and to combinations of TNF/IFN-gamma, TNF/LPS or IFN-gamma/LPS
• similar results are obtained with TLR2, TLR3 and TLR9 agonists

homeostasis/metabolism
• macrophges from mice where cre recombinase expression was induced produce less reactive NO in response to IFN-gamma, and to combinations of TNF/IFN-gamma, TNF/LPS or IFN-gamma/LPS
• similar results are obtained with TLR2, TLR3 and TLR9 agonists

hematopoietic system
• macrophges from mice where cre recombinase expression was induced produce less reactive NO in response to IFN-gamma, and to combinations of TNF/IFN-gamma, TNF/LPS or IFN-gamma/LPS
• similar results are obtained with TLR2, TLR3 and TLR9 agonists





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last database update
04/23/2024
MGI 6.23
The Jackson Laboratory