All Phenotypes Pax7<tm2.1(cre/ERT2)Fan> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pax7^{tm2.1(cre/ERT2)Fan}
targeted mutation 2.1, Chen-Ming Fan
MGI:4353154

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Pax7^tm1.1Thbr/Pax7^{tm2.1(cre/ERT2)Fan}	involves: 129S1/Sv * 129X1/SvJ	MGI:5548071
cn2	Mamstr^tm1.1Eno/Mamstr^tm1.1Eno Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺	involves: 129 * C57BL/6	MGI:5313414
cn3	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Pax7^tm1.1Fan/Pax7^{tm2.1(cre/ERT2)Fan}	involves: 129 * C57BL/6 * SJL	MGI:4353176
cn4	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Kdm6a^tm1.1Kaig/Y Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5779969
cn5	Kdm6a^tm1.1Kaig/Y Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5779970
cn6	Kdm6a^tm1.1Kaig/Kdm6a^tm1.1Kaig Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:5779968
cn7	Kras^tm4Tyj/Kras⁺ Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺ Trp53^tm1Brn/Trp53^tm1Brn	involves: 129/Sv * 129P2/OlaHsd * 129X1/SvJ * C57BL/6	MGI:5547938

Allelic Composition	Pax7^tm1.1Thbr/Pax7^{tm2.1(cre/ERT2)Fan}
Genetic Background	involves: 129S1/Sv * 129X1/SvJ

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax7^tm1.1Thbr mutation (0 available); any Pax7 mutation (39 available)
Pax7^{tm2.1(cre/ERT2)Fan} mutation (1 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:202693 )

N	• tamoxifen-treated mice do not exhibit centrally localized nuclei or differences in fiber diameter

abnormal skeletal muscle satellite cell proliferation ( J:202693 )

• reduced in tamoxifen-treated cultures

abnormal skeletal muscle morphology ( J:202693 )

• adult mice treated with tamoxifen exhibit rare atypical satellite cells with reduced heterochromatin condensation compared with control mice

skeletal muscle necrosis ( J:202693 )

• in a model of muscle regeneration, tamoxifen- and cardiotoxin-treated mice exhibit massive increase in necrotic fibers and fibrotic tissue compared with control mice

decreased skeletal muscle size ( J:202693 )

• in a model of muscle regeneration, tamoxifen- and cardiotoxin-treated mice exhibit reduced total muscle size compared with control mice

decreased satellite cell number ( J:202693 )

• after tamoxifen treatment

• after tamoxifen- and cardiotoxin-treatment

skeletal muscle fibrosis ( J:202693 )

• in a model of muscle regeneration, tamoxifen- and cardiotoxin-treated mice exhibit massive increase in necrotic fibers and fibrotic tissue compared with control mice

abnormal muscle regeneration ( J:202693 )

• in a model of muscle regeneration, tamoxifen- and cardiotoxin-treated mice exhibit reduced total muscle size and myofiber diameters with massive increase in necrotic fibers and fibrotic tissue compared with control mice

cellular

skeletal muscle necrosis ( J:202693 )

• in a model of muscle regeneration, tamoxifen- and cardiotoxin-treated mice exhibit massive increase in necrotic fibers and fibrotic tissue compared with control mice

abnormal skeletal muscle satellite cell proliferation ( J:202693 )

• reduced in tamoxifen-treated cultures

Allelic Composition	Mamstr^tm1.1Eno/Mamstr^tm1.1Eno Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺
Genetic Background	involves: 129 * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mamstr^tm1.1Eno mutation (0 available); any Mamstr mutation (19 available)
Pax7^{tm2.1(cre/ERT2)Fan} mutation (1 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

impaired skeletal muscle regeneration ( J:179880 )

• in tamoxifen treated mice at 3 and 7 days after cardiotoxin induced muscle damage mice show a significant decrease in the number of regenerating myofibers and persistence of necrotic fibers

Allelic Composition	Gt(ROSA)26Sor^tm1Sor/Gt(ROSA)26Sor⁺ Pax7^tm1.1Fan/Pax7^{tm2.1(cre/ERT2)Fan}
Genetic Background	involves: 129 * C57BL/6 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^tm1Sor mutation (8 available); any Gt(ROSA)26Sor mutation (942 available)
Pax7^tm1.1Fan mutation (1 available); any Pax7 mutation (39 available)
Pax7^{tm2.1(cre/ERT2)Fan} mutation (1 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

muscle phenotype ( J:150962 )

N	• following tamoxifen-treatment, injury-induced myogenesis and satellite cell characteristics are normal

abnormal myogenesis ( J:150962 )

• in culture, tamoxifen-treated P0 myoblasts exhibit defective expansive and myogenic potentials compared with control Pax7^{tm2.1(cre/ERT2)Fan} heterozygous myoblasts

• however, myoblasts from tamoxifen-treated adults exhibit normal expansive and myogenic potentials

abnormal muscle regeneration ( J:150962 )

• following tamoxifen treatment between P7 and P11, regeneration is severely compromised compared to in control Pax7^{tm2.1(cre/ERT2)Fan} heterozygotes

• however, following tamoxifen treatment between P14 to P18 and P21 to P25 regeneration capacity gradually increased to levels in control Pax7^{tm2.1(cre/ERT2)Fan} heterozygotes

• following tamoxifen treatment, myofibers continue to be incorporated into a regenerating muscle beyond P31 longer than in control Pax7^{tm2.1(cre/ERT2)Fan} heterozygotes

Allelic Composition	Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo}/Gt(ROSA)26Sor⁺ Kdm6a^tm1.1Kaig/Y Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm4(ACTB-tdTomato,-EGFP)Luo} mutation (10 available); any Gt(ROSA)26Sor mutation (942 available)
Kdm6a^tm1.1Kaig mutation (1 available); any Kdm6a mutation (38 available)
Pax7^{tm2.1(cre/ERT2)Fan} mutation (1 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

impaired skeletal muscle regeneration ( J:232700 )

• in tamoxifen-treated mice following CTX-induced muscle injury

Allelic Composition	Kdm6a^tm1.1Kaig/Y Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kdm6a^tm1.1Kaig mutation (1 available); any Kdm6a mutation (38 available)
Pax7^{tm2.1(cre/ERT2)Fan} mutation (1 available); any Pax7 mutation (39 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle precursor cell morphology ( J:232700 )

• muscle progenitor cells fail to differentiate ex vitro

impaired skeletal muscle regeneration ( J:232700 )

• following CTX-induced muscle injury, tamoxifen-treated mice exhibit decreased myofiber density with increased necrotic tissues and inflammatory cell infiltration compared with control mice

• however, mice exhibit regeneration of smaller caliber myofibers

Allelic Composition	Kdm6a^tm1.1Kaig/Kdm6a^tm1.1Kaig Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

muscle

abnormal muscle precursor cell morphology ( J:232700 )

• muscle progenitor cells fail to differentiate ex vitro

impaired skeletal muscle regeneration ( J:232700 )

• following CTX-induced muscle injury, tamoxifen-treated mice exhibit decreased myofiber density with increased necrotic tissues and inflammatory cell infiltration compared with control mice

• however, mice exhibit regeneration of smaller caliber myofibers

Allelic Composition	Kras^tm4Tyj/Kras⁺ Pax7^{tm2.1(cre/ERT2)Fan}/Pax7⁺ Trp53^tm1Brn/Trp53^tm1Brn
Genetic Background	involves: 129/Sv * 129P2/OlaHsd * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kras^tm4Tyj mutation (9 available); any Kras mutation (76 available)
Pax7^{tm2.1(cre/ERT2)Fan} mutation (1 available); any Pax7 mutation (39 available)
Trp53^tm1Brn mutation (18 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased tumor incidence ( J:205518 )

• when mice older than 6 weeks are given systemic tamoxifen treatment by intraperitoneal delivery, mice develop multiple tumors (avg. 3.9 per mouse) with 100% penetrance within 1-2 months; median tumor-free survival is 44 days

• tumors develop at various locations, including clinically relevant sites including the orbit

increased sarcoma incidence ( J:205518 )

• tamoxifen treated mice develop tumors displaying a histological spectrum ranging from undifferentiated pleomorphic sarcoma (UPS) to rhabdomyosarcoma (RMS)

• tumors mimic embryonic RMS, pleomorphic RMS, or myogenic or nonmyogenic UPS

• sarcomas can appear in the body wall (37%), the extremities (31%), head and neck (23%), with some being subcutaneous (9%)

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