Phenotypes associated with this allele

• Allele Symbol: Dpcd/Poll^{Gt(OST280355)Lex}
• Allele Name: gene trap OST280355, Lexicon Genetics
• Allele ID: MGI:4262238
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dpcd/Poll^Gt(OST280355)Lex/Dpcd/Poll^Gt(OST280355)Lex	involves: 129S5/SvEvBrd * C57BL/6Brd	MGI:4950027

Genotype
MGI:4950027

hm1

• Allelic Composition: Dpcd/Poll^{Gt(OST280355)Lex}/Dpcd/Poll^{Gt(OST280355)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6Brd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

abnormal survival ( J:171184 )

• born in slightly reduced numbers

growth/size/body

abnormal internal nares morphology ( J:185566 )

• nasal passages and sinuses were often filled with abundant mucopurulent exudate

decreased body size ( J:171184 , J:185566 )

• smaller than controls (J:171184)

situs inversus ( J:171184 , J:185566 )

• displayed by 50% of homozygotes (J:171184)

nervous system

hydrocephaly ( J:185566 )

• hydrocephalus accompanied by histological lesions consistent with ciliary dysfunction

dilated lateral ventricle ( J:171184 , J:185566 )

• moderate to marked (J:171184)

dilated third ventricle ( J:171184 , J:185566 )

• moderate to marked (J:171184)

craniofacial

domed cranium ( J:171184 , J:185566 )

• in severely affected individuals who are also inactive (J:171184)

• when the domed skull is less prominent activity is more normal (J:171184)

abnormal internal nares morphology ( J:185566 )

• nasal passages and sinuses were often filled with abundant mucopurulent exudate

behavior/neurological

decreased locomotor activity ( J:171184 )

• severely affected individuals who display domed skulls are also inactive

reproductive system

teratozoospermia ( J:171184 )

♂

short sperm flagellum ( J:171184 , J:185566 )

♂ (J:171184)

♂ (J:185566)

globozoospermia ( J:171184 , J:185566 )

♂ • round sperm heads (J:171184)

♂ (J:185566)

asthenozoospermia ( J:171184 , J:185566 )

♂ • immobile sperm (J:171184)

♂ (J:185566)

male infertility ( J:171184 , J:185566 )

♂ (J:171184)

♂ • male infertility with apparently normal spermatogenesis (J:185566)

respiratory system

abnormal internal nares morphology ( J:185566 )

• nasal passages and sinuses were often filled with abundant mucopurulent exudate

impaired mucociliary clearance ( J:171184 , J:185566 )

• severe nasal exudates (J:171184)

• nasal passages and sinuses were often filled with abundant mucopurulent exudate (J:185566)

skeleton

domed cranium ( J:171184 , J:185566 )

• in severely affected individuals who are also inactive (J:171184)

• when the domed skull is less prominent activity is more normal (J:171184)

hearing/vestibular/ear

increased susceptibility to otitis media ( J:185566 )

• otitis media present in most animals

immune system

increased susceptibility to otitis media ( J:185566 )

• otitis media present in most animals

cellular

teratozoospermia ( J:171184 )

♂

short sperm flagellum ( J:171184 , J:185566 )

♂ (J:171184)

♂ (J:185566)

globozoospermia ( J:171184 , J:185566 )

♂ • round sperm heads (J:171184)

♂ (J:185566)

asthenozoospermia ( J:171184 , J:185566 )

♂ • immobile sperm (J:171184)

♂ (J:185566)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
hydrocephalus		DOID:10908	OMIM:123155 OMIM:236600 OMIM:236635 OMIM:307000 OMIM:615219	J:185566
primary ciliary dyskinesia		DOID:9562	OMIM:PS244400	J:171184