Phenotypes associated with this allele

• Allele Symbol: Tomm5^{Gt(OST44663)Lex}
• Allele Name: gene trap OST44663, Lexicon Genetics
• Allele ID: MGI:4159168
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tomm5^Gt(OST44663)Lex/Tomm5^Gt(OST44663)Lex	involves: 129S5/SvEvBrd * C57BL/6	MGI:5432366

Genotype
MGI:5432366

hm1

• Allelic Composition: Tomm5^{Gt(OST44663)Lex}/Tomm5^{Gt(OST44663)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:186382 )

neonatal lethality, incomplete penetrance ( J:186382 )

• increased neonatal mortality

• no abnormal mortality after 8 weeks

respiratory system

respiratory system phenotype ( J:186382 )

N • little disruption or destruction of lung architecture

abnormal lung vasculature morphology ( J:186382 )

• no neovascularization in areas of organizing pneumonia

lung inflammation ( J:186382 )

• inflammatory cells are rare

• alveolar macrophage are always abundant in affected alveoli and surrounding air spaces

• most granulocytes are eosinophils

abnormal alveolar pore morphology ( J:186382 )

• fibrinogenic tissue sometimes extends between alveoli through the pores of Kohn

pulmonary fibrosis ( J:186382 )

• patchy intra-alveolar organizing pneumonia in some 6-7 week old mice

• mostly in right lung, lesions are rare in the left lung

• lesions composed of clearly defined and separated foci

• proliferative intra-alveolar fibrosis (Masson bodies)

immune system

thymus atrophy ( J:186382 )

• in some 6-7 week old mice

• almost complete depletion of thymocytes

increased eosinophil cell number ( J:186382 )

• diffuse moderate eosinophilic granulocytosis

lung inflammation ( J:186382 )

• inflammatory cells are rare

• alveolar macrophage are always abundant in affected alveoli and surrounding air spaces

• most granulocytes are eosinophils

hematopoietic system

thymus atrophy ( J:186382 )

• in some 6-7 week old mice

• almost complete depletion of thymocytes

increased bone marrow cell number ( J:186382 )

• diffuse moderate eosinophilic granulocytosis

increased eosinophil cell number ( J:186382 )

• diffuse moderate eosinophilic granulocytosis

cardiovascular system

abnormal lung vasculature morphology ( J:186382 )

• no neovascularization in areas of organizing pneumonia

endocrine/exocrine glands

thymus atrophy ( J:186382 )

• in some 6-7 week old mice

• almost complete depletion of thymocytes