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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Rnf7Gt(XE423)Byg
gene trap XE423, BayGenomics
MGI:4125996
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Rnf7Gt(XE423)Byg/Rnf7Gt(XE423)Byg involves: 129P2/OlaHsd MGI:4836044
hm2
Rnf7Gt(XE423)Byg/Rnf7Gt(XE423)Byg involves: 129P2/OlaHsd * C57BL/6 MGI:5301657
cn3
Krastm4Tyj/Kras+
Rnf7Gt(XE423)Byg/Rnf7tm1.1Ysun
involves: 129P2/OlaHsd * 129S4/SvJae MGI:5562910
cn4
Krastm4Tyj/Kras+
Rnf7Gt(XE423)Byg/Rnf7+
involves: 129P2/OlaHsd * 129S4/SvJae MGI:5562914
cx5
Nf1tm1Par/Nf1tm1Par
Rnf7Gt(XE423)Byg/Rnf7Gt(XE423)Byg
involves: 129 * C57BL/6 MGI:5301658


Genotype
MGI:4836044
hm1
Allelic
Composition
Rnf7Gt(XE423)Byg/Rnf7Gt(XE423)Byg
Genetic
Background
involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf7Gt(XE423)Byg mutation (0 available); any Rnf7 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• a derived embryonic stem line exposed to radiation exhibits decreased survival compared with similarly treated wild-type cells
• a derived embryonic stem line exposed to radiation exhibits increased apoptosis compared with similarly treated wild-type cells
• a derived embryonic stem line exposed to radiation exhibits increased reactive oxygen species generation compared with similarly treated wild-type cells




Genotype
MGI:5301657
hm2
Allelic
Composition
Rnf7Gt(XE423)Byg/Rnf7Gt(XE423)Byg
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf7Gt(XE423)Byg mutation (0 available); any Rnf7 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
• increased apoptosis in the developing spinal cord

mortality/aging

homeostasis/metabolism
• frequently seen in embryos at E10.5

embryo
• disrupted vasculature with missing major blood vessels and disorganized secondary branches at E9.5 and E10.5
• widespread apoptosis in embryos at E10.5
• decrease in the number of red blood cells in the blood islands

cellular
• impairment of cell cycle progression in neuronal precursor cells in the neocortex
• widespread apoptosis in embryos at E10.5
• increased apoptosis in the developing spinal cord
• cultured embryonic stem cells fail to differentiate into cystic embryoid bodies
• teratomas derived from embryonic stem cells grow more slowly
• decrease in proliferation of neuronal precursor cells in the neocortex

cardiovascular system
• decrease in the number of blood vessels surrounding and within the neuroepithelium
• disrupted vasculature with missing major blood vessels and disorganized secondary branches at E9.5 and E10.5
• frequently seen in embryos at E10.5

growth/size/body




Genotype
MGI:5562910
cn3
Allelic
Composition
Krastm4Tyj/Kras+
Rnf7Gt(XE423)Byg/Rnf7tm1.1Ysun
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Rnf7Gt(XE423)Byg mutation (0 available); any Rnf7 mutation (17 available)
Rnf7tm1.1Ysun mutation (0 available); any Rnf7 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival time of Ad-Cre treated mice is 37.9 weeks, with most mice dying by 60 weeks

neoplasm
• mice show reduced lung tumor burden following intratracheal administration of an adenovirus expressing Cre (Ad-Cre) compared to single Kras homozygotes, however the number of hyperplastic loci is not affected
• hyperplasia or adenomas from Ad-Cre treated mice show reduced proliferation compared to single Kras homozygotes




Genotype
MGI:5562914
cn4
Allelic
Composition
Krastm4Tyj/Kras+
Rnf7Gt(XE423)Byg/Rnf7+
Genetic
Background
involves: 129P2/OlaHsd * 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation (9 available); any Kras mutation (76 available)
Rnf7Gt(XE423)Byg mutation (0 available); any Rnf7 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• median survival time of Ad-Cre treated mice is 27.6 weeks, with all mice dying by 33 weeks

neoplasm
• mice develop lung adenomas with a few adenocarcinomas following intratracheal administration of an adenovirus expressing Cre (Ad-Cre)
• a few adenocarcinomas develop in mice following Ad-Cre administration

respiratory system
• mice develop lung adenomas with a few adenocarcinomas following intratracheal administration of an adenovirus expressing Cre (Ad-Cre)
• a few adenocarcinomas develop in mice following Ad-Cre administration




Genotype
MGI:5301658
cx5
Allelic
Composition
Nf1tm1Par/Nf1tm1Par
Rnf7Gt(XE423)Byg/Rnf7Gt(XE423)Byg
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Par mutation (4 available); any Nf1 mutation (157 available)
Rnf7Gt(XE423)Byg mutation (0 available); any Rnf7 mutation (17 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
cellular
• partial rescue of apoptosis in the spinal cord compared to mice null for Rnf7 alone
• rescue of neuronal apoptosis compared to mice null for Rnf7 alone
• decrease in proliferation of neuronal precursor cells in the neocortex

cardiovascular system
• partial restoration of angiogenesis in the head compared to mice null for Rnf7 alone

embryo

growth/size/body





Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory