Phenotypes associated with this allele
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf7Gt(XE423)Byg mutation
(0 available);
any
Rnf7 mutation
(17 available)
|
|
|
cellular
|
• a derived embryonic stem line exposed to radiation exhibits decreased survival compared with similarly treated wild-type cells
|
|
• a derived embryonic stem line exposed to radiation exhibits increased apoptosis compared with similarly treated wild-type cells
|
|
• a derived embryonic stem line exposed to radiation exhibits increased reactive oxygen species generation compared with similarly treated wild-type cells
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rnf7Gt(XE423)Byg mutation
(0 available);
any
Rnf7 mutation
(17 available)
|
|
|
nervous system
|
• increased apoptosis in the developing spinal cord
|
mortality/aging
|
• die between E11.5 and E12.5
|
homeostasis/metabolism
embryo
|
• disrupted vasculature with missing major blood vessels and disorganized secondary branches at E9.5 and E10.5
|
|
• widespread apoptosis in embryos at E10.5
|
|
• decrease in the number of red blood cells in the blood islands
|
cellular
|
• impairment of cell cycle progression in neuronal precursor cells in the neocortex
|
|
• widespread apoptosis in embryos at E10.5
|
|
• increased apoptosis in the developing spinal cord
|
|
• cultured embryonic stem cells fail to differentiate into cystic embryoid bodies
|
|
• teratomas derived from embryonic stem cells grow more slowly
• decrease in proliferation of neuronal precursor cells in the neocortex
|
cardiovascular system
|
• decrease in the number of blood vessels surrounding and within the neuroepithelium
|
|
• disrupted vasculature with missing major blood vessels and disorganized secondary branches at E9.5 and E10.5
|
|
• frequently seen in embryos at E10.5
|
growth/size/body
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation
(9 available);
any
Kras mutation
(76 available)
Rnf7Gt(XE423)Byg mutation
(0 available);
any
Rnf7 mutation
(17 available)
Rnf7tm1.1Ysun mutation
(0 available);
any
Rnf7 mutation
(17 available)
|
|
|
mortality/aging
|
• median survival time of Ad-Cre treated mice is 37.9 weeks, with most mice dying by 60 weeks
|
neoplasm
|
• mice show reduced lung tumor burden following intratracheal administration of an adenovirus expressing Cre (Ad-Cre) compared to single Kras homozygotes, however the number of hyperplastic loci is not affected
• hyperplasia or adenomas from Ad-Cre treated mice show reduced proliferation compared to single Kras homozygotes
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Krastm4Tyj mutation
(9 available);
any
Kras mutation
(76 available)
Rnf7Gt(XE423)Byg mutation
(0 available);
any
Rnf7 mutation
(17 available)
|
|
|
mortality/aging
|
• median survival time of Ad-Cre treated mice is 27.6 weeks, with all mice dying by 33 weeks
|
neoplasm
|
• mice develop lung adenomas with a few adenocarcinomas following intratracheal administration of an adenovirus expressing Cre (Ad-Cre)
|
|
• a few adenocarcinomas develop in mice following Ad-Cre administration
|
respiratory system
|
• mice develop lung adenomas with a few adenocarcinomas following intratracheal administration of an adenovirus expressing Cre (Ad-Cre)
|
|
• a few adenocarcinomas develop in mice following Ad-Cre administration
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nf1tm1Par mutation
(4 available);
any
Nf1 mutation
(157 available)
Rnf7Gt(XE423)Byg mutation
(0 available);
any
Rnf7 mutation
(17 available)
|
|
|
cellular
|
• partial rescue of apoptosis in the spinal cord compared to mice null for Rnf7 alone
• rescue of neuronal apoptosis compared to mice null for Rnf7 alone
|
|
• decrease in proliferation of neuronal precursor cells in the neocortex
|
cardiovascular system
|
• partial restoration of angiogenesis in the head compared to mice null for Rnf7 alone
|
embryo
growth/size/body