Phenotypes associated with this allele

• Allele Symbol: Usp24^Gt(XB614)Byg
• Allele Name: gene trap XB614, BayGenomics
• Allele ID: MGI:4124438
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Usp24^Gt(XB614)Byg/Usp24^Gt(XB614)Byg	B6.129P2-Usp24^Gt(XB614)Byg	MGI:6713580
hm2	Usp24^Gt(XB614)Byg/Usp24^Gt(XB614)Byg	involves: 129P2/OlaHsd * C57BL/6	MGI:6713577
ht3	Usp24^Gt(XB614)Byg/Usp24^+	involves: 129P2/OlaHsd * C57BL/6	MGI:6713578

Genotype
MGI:6713580

hm1

• Allelic Composition: Usp24^Gt(XB614)Byg/Usp24^Gt(XB614)Byg
• Genetic Background: B6.129P2-Usp24^Gt(XB614)Byg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:303991 )

• no living homozygous pups are found

Genotype
MGI:6713577

hm2

• Allelic Composition: Usp24^Gt(XB614)Byg/Usp24^Gt(XB614)Byg
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

mortality/aging

neonatal lethality, complete penetrance ( J:303991 )

• all pups are born alive but die within a few hours of birth

cellular

chromosomal instability ( J:303991 )

• MEFs from E13.5 embryos show an increase in the rate of chromosome missegregation, increase in chromosome lagging, increase in whole chromosome aneuploidy with most errors involving the gain or loss of 1-3 chromosomes

• however, no evidence of centrosome amplification or separation defects are seen

Genotype
MGI:6713578

ht3

• Allelic Composition: Usp24^Gt(XB614)Byg/Usp24⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

neoplasm

increased tumor incidence ( J:303991 )

• mice show an increase in tumors compared to wild-type mice at 18 months of age, showing lung tumors, small round blue cell tumors, lipomas, and liver tumors

increased incidence of tumors by chemical induction ( J:303991 )

• newborns exposed to the carcinogen dimethylbenz[a]anthracene (DMBA) show an increase in the incidence of skin tumors compared to wild-type mice

increased liver tumor incidence ( J:303991 )

increased lipoma incidence ( J:303991 )

increased lung tumor incidence ( J:303991 )

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:303991 )

• newborns exposed to the carcinogen dimethylbenz[a]anthracene (DMBA) show an increase in the incidence of skin tumors compared to wild-type mice

liver/biliary system

increased liver tumor incidence ( J:303991 )

respiratory system

increased lung tumor incidence ( J:303991 )