Usp24^Gt(XB614)Byg
Gene trapped Allele Detail

Summary

• Symbol: Usp24^Gt(XB614)Byg
• Name: ubiquitin specific peptidase 24; gene trap XB614, BayGenomics
• MGI ID: MGI:4124438
• Gene: Usp24 Location: Chr4:106173417-106298519 bp, + strand Genetic Position: Chr4, 49.44 cM, cytoband C7
• Alliance: Usp24^Gt(XB614)Byg page

Mutation origin

• Mutant Cell Line: XB614
• Germline Transmission: Earliest citation of germline transmission: J:303991
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Gene trapped (Null/knockout)
• Mutation: Insertion of gene trap vector Vector: pGT0pfs Vector Type: gene trap
• Mutation details: Trapped gene association determined by genome coordinate overlap and strand. This gene trap is inserted approximately 3819 nucleotides 3' to exon 37. The gene trap insertion interrupts a predicted armadillo fold and leads to a truncated protein, preserving 1,447 amino acids upstream of the insertion. The truncation will result in the loss of the USP_3 domain required for catalytic activity. No full-length protein is detectable but a beta-geo fusion protein is detected that is not catalytically active. (J:303991)
• Sequence Tags: Sequence tag details (1 tag)

  Tag ID	GenBank ID	Method	Tag Location (trapped strand)*	Select
  XB614	CC156306 ; (MGI Seq Detail)	5' RACE	Chr4:106245040-106249622 bp (+)
  * GRCm39; (strand of gene trap mutagenesis)

• Genome Context: Genome Browser view of this mutation;

  11 gene trap insertions have trapped this gene; View all gene trap sequence tags in this region

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Usp24 Mutation: 106 strains or lines available

Notes

All BayGenomics gene trap mutations were generated in either CGR8 or E14TG2a (129P2/OlaHsd) parental ES cell lines, with the majority in subline E14TG2a.4. The specific ES cell line in which each mutation was made is not specified.

References

• Original: J:141210 Mouse Genome Informatics (MGI) and National Center for Biotechnology Information (NCBI), Mouse Gene Trap Data Load from dbGSS. Database Download. 2008
• All: 3 reference(s)