All Phenotypes Elavl1<tm1Dkon> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Elavl1^tm1Dkon/Elavl1^tm1Dkon Tg(Lck-cre)I57Jxm/0	B6.Cg-Elavl1^tm1Dkon Tg(Lck-cre)I57Jxm	MGI:3847929
cn2	Elavl1^tm1Dkon/Elavl1^tm1Dkon Tg(Lck-cre)I57Jxm/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/?	B6.Cg-Elavl1^tm1Dkon Tg(Lck-cre)I57Jxm Tg(TcraH-Y,TcrbH-Y)71Vbo	MGI:3847930
cn3	Elavl1^tm1Dkon/Elavl1^tm1Dkon Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺	involves: 129P2/OlaHsd * C57BL/6 * CBA	MGI:3847920
cn4	Elavl1^tm1Dkon/Elavl1^tm1Dkon Tg(Tie1-cre)9Ref/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6	MGI:3847921

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal positive T cell selection ( J:148866 )

• there is a relative decrease in the DP thymocytes initiating (TCRbeta^intCD69^high) and undergoing (TCRbeta^highCD69^high)positive selection

increased double-negative T cell number ( J:148866 )

• double negative thymocyte numbers are significantly increased in number starting at 4 weeks of age

• the largest increase in numbers occur in the DN4 population

increased double-positive T cell number ( J:148866 )

• double positive thymocyte numbers are significantly increased in number starting at 10 weeks of age

decreased CD4-positive, alpha-beta T cell number ( J:148866 )

• splenic CD4⁺ T cell numbers are significantly less than controls

• with age, numbers drop below half that in controls

decreased CD8-positive, alpha-beta T cell number ( J:148866 )

• splenic CD8⁺ T cell numbers are significantly less than controls

• with age, numbers drop below half that in controls

increased single-positive T cell number ( J:148866 )

• double positive thymocyte numbers are significantly increased in number starting at 10 weeks of age

abnormal T cell physiology ( J:148866 )

• the ability of thymocytes to egress from the thymus is reduced in these mice

• the number of recent thymic emigrants in the periphery is reduced by about a third

• thymocytes migrate poorly to CXCL12 or CCR7

abnormal thymocyte activation ( J:148866 )

• about twice as many thymocytes in both the double negative and double positive subsets are in the S or G2/M phase

• thymocytes have a reduced response to TCR stimulation

hematopoietic system

abnormal positive T cell selection ( J:148866 )

• there is a relative decrease in the DP thymocytes initiating (TCRbeta^intCD69^high) and undergoing (TCRbeta^highCD69^high)positive selection

increased double-negative T cell number ( J:148866 )

• double negative thymocyte numbers are significantly increased in number starting at 4 weeks of age

• the largest increase in numbers occur in the DN4 population

increased double-positive T cell number ( J:148866 )

• double positive thymocyte numbers are significantly increased in number starting at 10 weeks of age

decreased CD4-positive, alpha-beta T cell number ( J:148866 )

• splenic CD4⁺ T cell numbers are significantly less than controls

• with age, numbers drop below half that in controls

decreased CD8-positive, alpha-beta T cell number ( J:148866 )

• splenic CD8⁺ T cell numbers are significantly less than controls

• with age, numbers drop below half that in controls

increased single-positive T cell number ( J:148866 )

• double positive thymocyte numbers are significantly increased in number starting at 10 weeks of age

abnormal T cell physiology ( J:148866 )

• the ability of thymocytes to egress from the thymus is reduced in these mice

• the number of recent thymic emigrants in the periphery is reduced by about a third

• thymocytes migrate poorly to CXCL12 or CCR7

abnormal thymocyte activation ( J:148866 )

• about twice as many thymocytes in both the double negative and double positive subsets are in the S or G2/M phase

• thymocytes have a reduced response to TCR stimulation

endocrine/exocrine glands

abnormal thymocyte activation ( J:148866 )

• about twice as many thymocytes in both the double negative and double positive subsets are in the S or G2/M phase

• thymocytes have a reduced response to TCR stimulation

Allelic Composition	Elavl1^tm1Dkon/Elavl1^tm1Dkon Tg(Lck-cre)I57Jxm/0 Tg(TcraH-Y,TcrbH-Y)71Vbo/?
Genetic Background	B6.Cg-Elavl1^tm1Dkon Tg(Lck-cre)I57Jxm Tg(TcraH-Y,TcrbH-Y)71Vbo

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elavl1^tm1Dkon mutation (1 available); any Elavl1 mutation (43 available)
Tg(Lck-cre)I57Jxm mutation (1 available)
Tg(TcraH-Y,TcrbH-Y)71Vbo mutation (3 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased thymocyte number ( J:148866 )

• there is a 50% increase in transgenic CD8 single-positive thymocytes in male mice

• however, there is no corresponding increase in transgenic CD8⁺ T cells in the periphery

abnormal negative T cell selection ( J:148866 )

• there is a 50% increase in transgenic CD8 single-positive thymocytes in male mice suggesting a defect in negative selection

hematopoietic system

increased thymocyte number ( J:148866 )

• there is a 50% increase in transgenic CD8 single-positive thymocytes in male mice

• however, there is no corresponding increase in transgenic CD8⁺ T cells in the periphery

abnormal negative T cell selection ( J:148866 )

• there is a 50% increase in transgenic CD8 single-positive thymocytes in male mice suggesting a defect in negative selection

endocrine/exocrine glands

increased thymocyte number ( J:148866 )

• there is a 50% increase in transgenic CD8 single-positive thymocytes in male mice

• however, there is no corresponding increase in transgenic CD8⁺ T cells in the periphery

Allelic Composition	Elavl1^tm1Dkon/Elavl1^tm1Dkon Edil3^{Tg(Sox2-cre)1Amc}/Edil3⁺
Genetic Background	involves: 129P2/OlaHsd * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Edil3^{Tg(Sox2-cre)1Amc} mutation (5 available); any Edil3 mutation (42 available)
Elavl1^tm1Dkon mutation (1 available); any Elavl1 mutation (43 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:149149 )

• mid-gestational embryonic lethality is not observed in the offspring of male Tg(Sox2-cre)1Amc transgenics and female Elavl1^tm1.1Dkon homozygotes

• instead fetuses die between E17.5 and E19.5

embryo

small limb buds ( J:149149 )

• E14.5 embryos possess limbs of reduced size, which in many cases lacked definable digits and resemble E12.5 limb buds

skeleton

abnormal craniofacial bone morphology ( J:149149 )

• craniofacial osteogenic ossification is delayed in 80% of E17.5 embryos with the exception of mandibles that develop normally

split xiphoid process ( J:149149 )

• sternums in E17.5-E18.5 embryos have a xiphoid process that is open and bifid

abnormal vertebrae development ( J:149149 )

• vertebrae are not ossified in E18.5 embryos and lack the articular processes that connect vertebrae

synostosis ( J:149149 )

• radial and ulnar bones are fused in more than 40% of the E17.5 embryos

delayed endochondral bone ossification ( J:149149 )

• skeletal structures of E17.5- E19.5 embryos remained primarily cartilaginous

• long bones are shorter in null embryos and show minimal ossification zones in scapulae, femurs, and tibia

craniofacial

abnormal craniofacial bone morphology ( J:149149 )

• craniofacial osteogenic ossification is delayed in 80% of E17.5 embryos with the exception of mandibles that develop normally

midline facial cleft ( J:149149 )

• less than 15% of E17.5 embryos have severe nasal clefting

immune system

abnormal spleen development ( J:149149 )

• spleens are absent in E15.5 and E19.5 embryos

absent spleen ( J:149149 )

• spleens are absent in E15.5 and E19.5 embryos

limbs/digits/tail

small limb buds ( J:149149 )

• E14.5 embryos possess limbs of reduced size, which in many cases lacked definable digits and resemble E12.5 limb buds

syndactyly ( J:149149 )

• is observed within both forelimbs (carpal to metacarpal) and hindlimbs (tarsal to metatarsal) of E17.5 embryos

short limbs ( J:149149 )

• fetal mice have short limbs

• long bones are shorter in null embryos and show minimal ossification zones in the femurs and tibia

respiratory system

abnormal lung development ( J:149149 )

• major dysmorphologies occur in the lung of E19.5 embyros

hematopoietic system

abnormal spleen development ( J:149149 )

• spleens are absent in E15.5 and E19.5 embryos

absent spleen ( J:149149 )

• spleens are absent in E15.5 and E19.5 embryos

growth/size/body

midline facial cleft ( J:149149 )

• less than 15% of E17.5 embryos have severe nasal clefting

Allelic Composition	Elavl1^tm1Dkon/Elavl1^tm1Dkon Tg(Tie1-cre)9Ref/0
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elavl1^tm1Dkon mutation (1 available); any Elavl1 mutation (43 available)
Tg(Tie1-cre)9Ref mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

normal phenotype

no abnormal phenotype detected ( J:149149 )

• mice are born healthy and fertile suggesting that the the midgestational embryonic lethality observed in Elavl1 null mice results from placental failure due to extraembryonic defects

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