Phenotypes associated with this allele

• Allele Symbol: Tdrd6^tm1Jess
• Allele Name: targeted mutation 1, Rolf Jessberger
• Allele ID: MGI:3847699
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tdrd6^tm1Jess/Tdrd6^tm1Jess	either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)	MGI:3847710

Genotype
MGI:3847710

hm1

• Allelic Composition: Tdrd6^tm1Jess/Tdrd6^tm1Jess
• Genetic Background: either: (involves: 129S6/SvEvTac * C57BL/6) or (involves: 129S1/Sv * 129X1/SvJ * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

azoospermia ( J:148942 )

♂ • epididymes lack sperm and elongated spermatids unlike in wild-type mice

♂ • however, earlier spermatogenic cells are present

increased male germ cell apoptosis ( J:148942 )

♂ • apoptosis of male germ cells is increased 2-fold after P18 compared to in wild-type mice

small testis ( J:148942 )

♂ • at 6 weeks, mice exhibit up to 25% reduction in testes size compared to in wild-type mice

arrest of spermatogenesis ( J:148942 )

♂ • at stage V

male infertility ( J:148942 )

♂

cellular

abnormal cell morphology ( J:148942 )

• the chromatoid body architecture is distorted compared to in wild-type mice

azoospermia ( J:148942 )

♂ • epididymes lack sperm and elongated spermatids unlike in wild-type mice

♂ • however, earlier spermatogenic cells are present

increased male germ cell apoptosis ( J:148942 )

♂ • apoptosis of male germ cells is increased 2-fold after P18 compared to in wild-type mice

endocrine/exocrine glands

small testis ( J:148942 )

♂ • at 6 weeks, mice exhibit up to 25% reduction in testes size compared to in wild-type mice