Tdrd6^tm1Jess
Targeted Allele Detail

Summary

• Symbol: Tdrd6^tm1Jess
• Name: tudor domain containing 6; targeted mutation 1, Rolf Jessberger
• MGI ID: MGI:3847699
• Gene: Tdrd6 Location: Chr17:43926226-43941190 bp, - strand Genetic Position: Chr17, 19.75 cM
• Alliance: Tdrd6^tm1Jess page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:148942
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: 129S6/SvEvTac or 129S1/Sv and 129X1/SvJ

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 1 was replaced with a truncated human CD4 cDNA and a floxed puromycin resistance cassette. The absence of protein expression was confirmed by western blot analysos of testes extracts. (J:148942)

Expression

In Mice Carrying this Mutation:	65 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tdrd6 Mutation: 80 strains or lines available

Notes

ES cells were either R1 (129S1/Sv and 129X1/SvJ) or W4 (129S6/SvEvTac)

References

• Original: J:148942 Vasileva A, et al., Tdrd6 is required for spermiogenesis, chromatoid body architecture, and regulation of miRNA expression. Curr Biol. 2009 Apr 28;19(8):630-9
• All: 4 reference(s)