Analysis Tools|
Allele Symbol Allele Name Allele ID |
Six2tm3(EGFP/cre/ERT2)Amc targeted mutation 3, Andrew P McMahon MGI:3845222 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• die shortly after birth
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• at E14.5, a decrease in proliferation of mesenchymal cells is seen in the medial tip portion of the palatal shelves in embryos with a cleft palate
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• premature ossification of the palatal shelf bones (maxillary process and palatine bone) at E16.5 in embryos with cleft palate
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• at E16.5 palatal shelves fail to extend to the midline
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• in 22% of embryos
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• at E14.5
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• premature ossification of the palatal shelf bones (maxillary process and palatine bone) at E16.5 in embryos with cleft palate
|
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• at E14.5, a decrease in proliferation of mesenchymal cells is seen in the medial tip portion of the palatal shelves in embryos with a cleft palate
|
|
• premature ossification of the palatal shelf bones (maxillary process and palatine bone) at E16.5 in embryos with cleft palate
|
|
• at E16.5 palatal shelves fail to extend to the midline
|
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• in 22% of embryos
|
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• at E14.5
|
|
• at E14.5, a decrease in proliferation of mesenchymal cells is seen in the medial tip portion of the palatal shelves in embryos with a cleft palate
|
|
• premature ossification of the palatal shelf bones (maxillary process and palatine bone) at E16.5 in embryos with cleft palate
|
|
• at E16.5 palatal shelves fail to extend to the midline
|
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• in 22% of embryos
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• at E14.5
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| cleft palate | DOID:674 | J:285711 | ||
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• mice are viable, fertile, and display no obvious abnormalities
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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