Phenotypes associated with this allele

• Allele Symbol: Map3k6^tm1Hijo
• Allele Name: targeted mutation 1, Hidenori Ichijo
• Allele ID: MGI:3843985
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Map3k6^tm1Hijo/Map3k6^tm1Hijo	B6.129P2-Map3k6^tm1Hijo	MGI:3844017
ht2	Map3k6^tm1Hijo/Map3k6^+	B6.129P2-Map3k6^tm1Hijo	MGI:3844018
cx3	Map3k5^tm1Hijo/Map3k5^tm1Hijo Map3k6^tm1Hijo/Map3k6^tm1Hijo	B6.129-Map3k6^tm1Hijo Map3k5^tm1Hijo	MGI:3844019

Genotype
MGI:3844017

hm1

• Allelic Composition: Map3k6^tm1Hijo/Map3k6^tm1Hijo
• Genetic Background: B6.129P2-Map3k6^tm1Hijo

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:148044 )

• primary keratinocytes and epidermal cells in the intact mouse are more resistant to DMBA induced apoptosis compared to wild-type cells

increased incidence of tumors by chemical induction ( J:148044 )

• increased incidence of papillomas in a 2-stage skin tumorigenesis model using DMBA and TPA compared to wild-type controls and heterozygous mutant mice

neoplasm

neoplasm ( J:148044 )

N • no increase in spontaneous tumorigenesis is detected

increased incidence of tumors by chemical induction ( J:148044 )

• increased incidence of papillomas in a 2-stage skin tumorigenesis model using DMBA and TPA compared to wild-type controls and heterozygous mutant mice

integument

integument phenotype ( J:148044 )

N • despite high levels of endogenous gene expression in the skin, no gross abnormalities are detected in the skin

decreased keratinocyte apoptosis ( J:148044 )

• keratinocytes are more resistant to UVA induced apoptosis compared to wild-type cells

cellular

decreased keratinocyte apoptosis ( J:148044 )

• keratinocytes are more resistant to UVA induced apoptosis compared to wild-type cells

Genotype
MGI:3844018

ht2

• Allelic Composition: Map3k6^tm1Hijo/Map3k6⁺
• Genetic Background: B6.129P2-Map3k6^tm1Hijo

homeostasis/metabolism

increased incidence of tumors by chemical induction ( J:148044 )

• increased incidence of papillomas in a 2-stage skin tumorigenesis model using DMBA and TPA compared to wild-type controls but decreased compared to homozygous mutant mice

neoplasm

increased incidence of tumors by chemical induction ( J:148044 )

• increased incidence of papillomas in a 2-stage skin tumorigenesis model using DMBA and TPA compared to wild-type controls but decreased compared to homozygous mutant mice

Genotype
MGI:3844019

cx3

• Allelic Composition: Map3k5^tm1Hijo/Map3k5^tm1Hijo; Map3k6^tm1Hijo/Map3k6^tm1Hijo
• Genetic Background: B6.129-Map3k6^tm1Hijo Map3k5^tm1Hijo

homeostasis/metabolism

decreased physiological sensitivity to xenobiotic ( J:148044 )

• hyperplasia following TPA exposure is milder than in wild type controls or mice homozygous for Map3k6^tm1Hijo alone

neoplasm

neoplasm ( J:148044 )

N • unlike mice homozygous for Map3k6^tm1Hijo alone, no increase in chemically induced skin tumorigenesis is detected