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Targeted Allele Detail
Symbol: Map3k5tm1Hijo
Name: mitogen-activated protein kinase kinase kinase 5; targeted mutation 1, Hidenori Ichijo
MGI ID: MGI:3046838
Synonyms: ASK-, ASK1-
Gene: Map3k5  Location: Chr10:19810218-20018499 bp, + strand  Genetic Position: Chr10, 9.35 cM
Alliance: Map3k5tm1Hijo page
Germline Transmission:  Earliest citation of germline transmission: J:88612
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsThe coding region of exon 1 was replaced with a cassette containing GFP and PGK-neo. The absence of normal protein from homozygous mutant mice was indicated by both Western blot analysis of MEFs and immune complex kinase assay of various tissues and MEFs. (J:88612)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
Carrying any Map3k5 Mutation:  50 strains or lines available
Original:  J:88612 Tobiume K, et al., ASK1 is required for sustained activations of JNK/p38 MAP kinases and apoptosis. EMBO Rep. 2001 Mar;2(3):222-8
All:  58 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory