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Targeted Allele Detail
Symbol: Map3k6tm1Hijo
Name: mitogen-activated protein kinase kinase kinase 6; targeted mutation 1, Hidenori Ichijo
MGI ID: MGI:3843985
Gene: Map3k6  Location: Chr4:132968129-132980240 bp, + strand  Genetic Position: Chr4, 66.25 cM
Alliance: Map3k6tm1Hijo page
Germline Transmission:  Earliest citation of germline transmission: J:148044
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA lacZ cassette with a nuclear localization signal and a reverse orientation pgk-neo cassette replaced exons 1 - 5 via homologous recombination. Immunoblot analysis of homozygous MEFs and primary keratinocytes confirmed the absence of protein expression. (J:148044)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Map3k6 Mutation:  34 strains or lines available
Original:  J:148044 Iriyama T, et al., ASK1 and ASK2 differentially regulate the counteracting roles of apoptosis and inflammation in tumorigenesis. EMBO J. 2009 Apr 8;28(7):843-53
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
MGI 6.22
The Jackson Laboratory