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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(KRT5-Akt1*)Jmpa
transgene insertion, Jesus M Paramio
MGI:3842829
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Rb1tm2Brn/Rb1tm2Brn
Tg(KRT14-cre)8Brn/0
Tg(KRT5-Akt1*)Jmpa/0 		involves: 129 * C57BL/6 * DBA/2 * DBA/2J * FVB/N MGI:3842836
cn2
 		Tg(KRT14-cre)8Brn/0
Tg(KRT5-Akt1*)Jmpa/0
Trp53tm1Brn/Trp53tm1Brn 		involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * DBA/2J * FVB/N MGI:3842833
tg3
 		Tg(KRT5-Akt1*)Jmpa/0 involves: C57BL/6 * DBA/2 * DBA/2J * FVB/N MGI:3842834


Genotype
MGI:3842836
cn1
Allelic
Composition		 Rb1tm2Brn/Rb1tm2Brn
Tg(KRT14-cre)8Brn/0
Tg(KRT5-Akt1*)Jmpa/0
Genetic
Background		 involves: 129 * C57BL/6 * DBA/2 * DBA/2J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rb1tm2Brn mutation (2 available); any Rb1 mutation (116 available)
Tg(KRT14-cre)8Brn mutation (3 available)
Tg(KRT5-Akt1*)Jmpa mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased tumor incidence ( J:144831 )
• pathologic characteristics of oral lesions and tumor development rate are the same as in Tg(KRT5-Akt1*)Jmpa mice

craniofacial
abnormal oral mucosa morphology ( J:144831 )
• pathologic characteristics of oral lesions and tumor development rate are the same as in Tg(KRT5-Akt1*)Jmpa mice

digestive/alimentary system
abnormal oral mucosa morphology ( J:144831 )
• pathologic characteristics of oral lesions and tumor development rate are the same as in Tg(KRT5-Akt1*)Jmpa mice

growth/size/body
abnormal oral mucosa morphology ( J:144831 )
• pathologic characteristics of oral lesions and tumor development rate are the same as in Tg(KRT5-Akt1*)Jmpa mice




Genotype
MGI:3842833
cn2
Allelic
Composition		 Tg(KRT14-cre)8Brn/0
Tg(KRT5-Akt1*)Jmpa/0
Trp53tm1Brn/Trp53tm1Brn
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA/2 * DBA/2J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(KRT14-cre)8Brn mutation (3 available)
Tg(KRT5-Akt1*)Jmpa mutation (0 available)
Trp53tm1Brn mutation (20 available); any Trp53 mutation (238 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
abnormal tumor morphology ( J:144831 )
• proliferation is increased in oral tumors compared to in Tg(KRT5-Akt1*)Jmpa oral tumors
• the number of blood vessels is enhanced in dysplasias and tumors compared to normal oral epithelia in Tg(KRT5-Akt1*)Jmpa mice
increased carcinoma incidence ( J:144831 )
• mice develop malignant carcinomas in the oral cavity affecting the palate, ventral side of the tongue, and the external and internal sides of the lips unlike in wild-type mice
• mice develop tumors earlier than in mice expressing Trp53
• mice develop lymph node metastases and lung micrometastases from undifferentiated highly aggressive primary tumors

cellular
increased cell proliferation ( J:144831 )
• cell proliferation of nonlesion oral epithelia is greater than in wild-type and Tg(KRT5-Akt1*)Jmpa mice
increased keratinocyte proliferation ( J:144831 )
• oral keratinocyte proliferation is greater than in wild-type cells

integument
increased keratinocyte proliferation ( J:144831 )
• oral keratinocyte proliferation is greater than in wild-type cells

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
head and neck squamous cell carcinoma DOID:5520 OMIM:275355
 J:144831




Genotype
MGI:3842834
tg3
Allelic
Composition		 Tg(KRT5-Akt1*)Jmpa/0
Genetic
Background		 involves: C57BL/6 * DBA/2 * DBA/2J * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
neoplasm
increased trichoepithelioma incidence ( J:144831 )
• mice exhibit palatine and tongue gland hyperplasia with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma
abnormal tumor morphology ( J:144831 )
• the number of blood vessels is enhanced in dysplasias and tumos compared to normal oral epithelia in Tg(KRT5-Akt1*)Jmpa mice
increased carcinoma incidence ( J:144831 )
• mice exhibit palatine and tongue gland hyperplasia with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma
increased adenocarcinoma incidence ( J:144831 )
• mice exhibit palatine and tongue gland hyperplasia with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma

digestive/alimentary system
abnormal oral mucosa morphology ( J:144831 )
• cell proliferation of nontumoral oral epithelia is mildly increased compared to in wild-type mice
• all mice develop pretumoral lesions in the oral cavity unlike wild-type mice
oral erythroplakia ( J:144831 )
• mice develop erythroplakia in the palate, cheeks, and lips unlike wild-type mice
abnormal sublingual gland morphology ( J:144831 )
• hyperplastic with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma
abnormal palatine gland morphology ( J:144831 )
• hyperplastic with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma

cellular
decreased keratinocyte proliferation ( J:144831 )
• oral keratinocyte proliferation is arrested unlike in wild-type cells
increased cell proliferation ( J:144831 )
• cell proliferation of nonlesion oral epithelia is greater than in wild-type mice

craniofacial
abnormal oral mucosa morphology ( J:144831 )
• cell proliferation of nontumoral oral epithelia is mildly increased compared to in wild-type mice
• all mice develop pretumoral lesions in the oral cavity unlike wild-type mice
oral erythroplakia ( J:144831 )
• mice develop erythroplakia in the palate, cheeks, and lips unlike wild-type mice

endocrine/exocrine glands
abnormal sublingual gland morphology ( J:144831 )
• hyperplastic with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma
abnormal palatine gland morphology ( J:144831 )
• hyperplastic with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma

integument
decreased keratinocyte proliferation ( J:144831 )
• oral keratinocyte proliferation is arrested unlike in wild-type cells
increased trichoepithelioma incidence ( J:144831 )
• mice exhibit palatine and tongue gland hyperplasia with signs of adenocarcinomatous conversion, in situ carcinomas of the oral mucosa, and lip trichoepithelioma

growth/size/body
abnormal oral mucosa morphology ( J:144831 )
• cell proliferation of nontumoral oral epithelia is mildly increased compared to in wild-type mice
• all mice develop pretumoral lesions in the oral cavity unlike wild-type mice
oral erythroplakia ( J:144831 )
• mice develop erythroplakia in the palate, cheeks, and lips unlike wild-type mice
oral leukoplakia ( J:144831 )




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09/30/2025
MGI 6.24 		The Jackson Laboratory