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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Lats1tm1Noj
targeted mutation 1, Hiroshi Nojima
MGI:3840659
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Lats1tm1Noj/Lats1tm1Noj involves: 129S2/SvPas * C57BL/6 MGI:4412186
cn2
 		Lats1tm1Noj/Lats1tm1Noj
Lats2tm1.1Dupa/Lats2tm1.1Dupa 		involves: 129P2/OlaHsd * 129S2/SvPas MGI:5660302
cn3
 		Lats1tm1Noj/Lats1tm1Noj
Lats2tm1.1Dupa/Lats2tm1.1Dupa
Wwtr1tm1.2Eno/Wwtr1tm1.2Eno
Yap1tm1.1Dupa/Yap1tm1.1Dupa 		involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas MGI:5660349


Genotype
MGI:4412186
hm1
Allelic
Composition		 Lats1tm1Noj/Lats1tm1Noj
Genetic
Background		 involves: 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lats1tm1Noj mutation (1 available); any Lats1 mutation (48 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:200232 )
• fewer than expected mice are present at birth

cellular
abnormal centrosome morphology ( J:200232 )
• centrosomal overduplication in mouse embryonic fibroblasts that gradually diminishes over successive passages
abnormal cell physiology ( J:200232 )
• mouse embryonic fibroblasts escape contact inhibition 5 days after the confluent stage and pile up after 12 days unlike wild-type mice
abnormal mitosis ( J:200232 )
• mouse embryonic fibroblasts exhibit chromosomal misalignment, multipolar spindle formation, chromosomal bridging and cytokinesis failure unlike wild-type cells
abnormal mitotic spindle morphology ( J:200232 )
• multipolar spindle formation in mouse embryonic fibroblasts
increased fibroblast proliferation ( J:200232 )
• mouse embryonic fibroblasts grown on nanoculture plates or 3D collagen gels exhibit accelerated growth and spheroid formation compared with wild-type cells

growth/size/body
decreased body weight ( J:200232 )
• until 4 weeks after birth
postnatal growth retardation ( J:200232 )

neoplasm
neoplasm ( J:200232 )
N
• mice do not develop tumors unlike Lats1tm1Tx homozygotes
abnormal tumor morphology ( J:200232 )
• mouse embryonic fibroblasts injected into nude mice produce tumors that grow slower than ordinary epithelial cancer cells unlike wild-type cells




Genotype
MGI:5660302
cn2
Allelic
Composition		 Lats1tm1Noj/Lats1tm1Noj
Lats2tm1.1Dupa/Lats2tm1.1Dupa
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lats1tm1Noj mutation (1 available); any Lats1 mutation (48 available)
Lats2tm1.1Dupa mutation (1 available); any Lats2 mutation (42 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal bile duct epithelium morphology ( J:223215 )
• extensive proliferation of cryokeratin-positive biliary epithelial cells observed in liver following adenovirus expressing Cre recombinase (Ad-Cre) injection

liver/biliary system
abnormal bile duct epithelium morphology ( J:223215 )
• extensive proliferation of cryokeratin-positive biliary epithelial cells observed in liver following adenovirus expressing Cre recombinase (Ad-Cre) injection
enlarged liver ( J:223215 )
• mice develop hepatomegaly 8 weeks after Ad-Cre injection
increased liver weight ( J:223215 )
• liver size reaches 30% of body weight 8 weeks after Ad-Cre injection

growth/size/body
enlarged liver ( J:223215 )
• mice develop hepatomegaly 8 weeks after Ad-Cre injection
increased liver weight ( J:223215 )
• liver size reaches 30% of body weight 8 weeks after Ad-Cre injection




Genotype
MGI:5660349
cn3
Allelic
Composition		 Lats1tm1Noj/Lats1tm1Noj
Lats2tm1.1Dupa/Lats2tm1.1Dupa
Wwtr1tm1.2Eno/Wwtr1tm1.2Eno
Yap1tm1.1Dupa/Yap1tm1.1Dupa
Genetic
Background		 involves: 129P2/OlaHsd * 129S/SvEv * 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lats1tm1Noj mutation (1 available); any Lats1 mutation (48 available)
Lats2tm1.1Dupa mutation (1 available); any Lats2 mutation (42 available)
Wwtr1tm1.2Eno mutation (0 available); any Wwtr1 mutation (23 available)
Yap1tm1.1Dupa mutation (2 available); any Yap1 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
endocrine/exocrine glands
abnormal bile duct epithelium morphology ( J:223215 )
• slight proliferation of cryokeratin-positive biliary epithelial cells observed in liver following adenovirus expressing Cre recombinase (Ad-Cre) injection; in contrast to overproliferation found in homozygous Lats2tm1.1Dupa Lats1tm1Noj

liver/biliary system
abnormal bile duct epithelium morphology ( J:223215 )
• slight proliferation of cryokeratin-positive biliary epithelial cells observed in liver following adenovirus expressing Cre recombinase (Ad-Cre) injection; in contrast to overproliferation found in homozygous Lats2tm1.1Dupa Lats1tm1Noj
enlarged liver ( J:223215 )
• mice develop slight hepatomegaly 8 weeks after Ad-Cre injection; in contrast to severe hepatomegaly developed by homozygous Lats2tm1.1Dupa Lats1tm1Noj

growth/size/body
enlarged liver ( J:223215 )
• mice develop slight hepatomegaly 8 weeks after Ad-Cre injection; in contrast to severe hepatomegaly developed by homozygous Lats2tm1.1Dupa Lats1tm1Noj




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory