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Allele Symbol Allele Name Allele ID |
Gt(ROSA)26Sortm2(SNCA*119)Djmo targeted mutation 2, Darren Moore MGI:3840596 |
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| Summary |
4 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• increased levels of norepinephrine observed in striatum in 10-11 month old mice
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• 32% reduction in levels of striatal dopamine observed in 10-11 month old mice
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• increased levels of 5-HT observed in prefrontal cortex in 10-11 month old mice
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Parkinson's disease 1 | DOID:0060367 |
OMIM:168601 |
J:150777 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• there are significant reductions in the levels of striatal dopamine (~32%), dihydroxyphenylacetic acid (~46%) and homovanillic acid (~33%) compared to controls at 10-11 months of age
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• norepinephrine levels in the striatum are elevated at 10-11 months of age compared to controls
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• 5-HT levels are elevated in the prefrontal cortex at 10-11 months of age compared to controls
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Parkinson's disease 1 | DOID:0060367 |
OMIM:168601 |
J:150777 | |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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