Phenotypes associated with this allele

• Allele Symbol: Sell^tm3Hyn
• Allele Name: targeted mutation 3, Richard Hynes
• Allele ID: MGI:3839977
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Sell^tm3Hyn/Sell^tm3Hyn Selp^tm1Hyn/Selp^tm1Hyn	involves: 129S2/SvPas * C57BL/6	MGI:3840202

Genotype
MGI:3840202

cx1

• Allelic Composition: Sell^tm3Hyn/Sell^tm3Hyn; Selp^tm1Hyn/Selp^tm1Hyn
• Genetic Background: involves: 129S2/SvPas * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

impaired leukocyte tethering or rolling ( J:57973 )

• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF

increased leukocyte cell number ( J:57973 )

• leukocyte numbers are slightly increased

increased eosinophil cell number ( J:57973 )

• eosinophil numbers are about 4-fold higher in the blood

increased neutrophil cell number ( J:57973 )

• neutrophils numbers are slightly increased

impaired eosinophil recruitment ( J:57973 )

• 2-fold fewer eosinophils are recruited to the peritoneum in response to ragweed allergen challenge

impaired neutrophil recruitment ( J:57973 )

• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice

• lower numbers of neutrophils are observed than those elicited from mice that are null homozygotes for just one gene

• numbers of neutrophils increased between 8- 24 hours post injection whereas in wild-type mice they decrease

hematopoietic system

impaired leukocyte tethering or rolling ( J:57973 )

• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF

increased leukocyte cell number ( J:57973 )

• leukocyte numbers are slightly increased

increased eosinophil cell number ( J:57973 )

• eosinophil numbers are about 4-fold higher in the blood

increased neutrophil cell number ( J:57973 )

• neutrophils numbers are slightly increased

impaired eosinophil recruitment ( J:57973 )

• 2-fold fewer eosinophils are recruited to the peritoneum in response to ragweed allergen challenge

impaired neutrophil recruitment ( J:57973 )

• neutrophil influx in thioglycollate-induced peritonitis is inhibited at 2, 4, and 8 hours after injection compared to wild-type mice

• lower numbers of neutrophils are observed than those elicited from mice that are null homozygotes for just one gene

• numbers of neutrophils increased between 8- 24 hours post injection whereas in wild-type mice they decrease

cellular

impaired leukocyte tethering or rolling ( J:57973 )

• rolling leukocytes are virtually absent within the mesenteric venules of mice treated with TNF