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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm2(GFP/tetX)Gld
targeted mutation 2, Martyn Goulding
MGI:3839913
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm2(GFP/tetX)Gld/Gt(ROSA)26Sor+
Tg(Nes-cre)1Kln/0 		involves: C57BL/6 * SJL MGI:3839916
cn2
 		Gt(ROSA)26Sortm2(GFP/tetX)Gld/Gt(ROSA)26Sor+
Sim1tm1.1(cre)Gld/Sim1+ 		involves: C57BL/6 * SJL MGI:3839917


Genotype
MGI:3839916
cn1
Allelic
Composition		 Gt(ROSA)26Sortm2(GFP/tetX)Gld/Gt(ROSA)26Sor+
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(GFP/tetX)Gld mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Nes-cre)1Kln mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal CNS synaptic transmission ( J:147245 )
• block of synaptic transmission between spinal neurons that is necessary for fictive locomotion




Genotype
MGI:3839917
cn2
Allelic
Composition		 Gt(ROSA)26Sortm2(GFP/tetX)Gld/Gt(ROSA)26Sor+
Sim1tm1.1(cre)Gld/Sim1+
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm2(GFP/tetX)Gld mutation (0 available); any Gt(ROSA)26Sor mutation (942 available)
Sim1tm1.1(cre)Gld mutation (0 available); any Sim1 mutation (52 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal CNS synaptic transmission ( J:147245 )
• electroneurogram recordings from ventral roots indicates a suppression of synaptic transmission disrupting locomotor rhythm
• outputs from spinal cords show increased variability in the duration of individual motor bursts and in the length of the step cycle period which may be coupled with asymmetry in the duration of flexor bursts between the right and left sides of the spinal cord
• spinal cords show impaired production of locomotor like oscillations following induction with NMDA and 5-hydroxytryptamine or after electrical stimulation of sensory afferents




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory