Sim1^{tm1.1(cre)Gld}
Targeted Allele Detail

Summary

• Symbol: Sim1^{tm1.1(cre)Gld}
• Name: single-minded family bHLH transcription factor 1; targeted mutation 1.1, Martyn Goulding
• MGI ID: MGI:3839912
• Synonyms: Sim1^Cre
• Gene: Sim1 Location: Chr10:50770850-50865248 bp, + strand Genetic Position: Chr10, 24.87 cM, cytoband B3-B4
• Alliance: Sim1^{tm1.1(cre)Gld} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:147245
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Recombinase)
• Mutations: Insertion, Intragenic deletion
• Sim1^{tm1.1(cre)Gld} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Sim1 (MGI:98306)

• Mutation details: A cre gene followed by an frt flanked neo cassette were inserted via homologous recombination replacing the first exon. The neo cassette was then removed by Flp mediated recombination. At E11.5 Cre activity mirrors the pattern of endogenous Sim1 mRNA expression. (J:147245)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Sim1 (mouse) Summary of all recombinase alleles driven by Sim1. Alliance mouse Sim1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sim1 Mutation: 52 strains or lines available

References

• Original: J:147245 Zhang Y, et al., V3 spinal neurons establish a robust and balanced locomotor rhythm during walking. Neuron. 2008 Oct 9;60(1):84-96
• All: 13 reference(s)