All Phenotypes Gt(ROSA)26Sor<tm2(sb11)Njen> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Gt(ROSA)26Sor^{tm2(sb11)Njen}
targeted mutation 2, Nancy A Jenkins
MGI:3839796

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Aicda^tm1(cre)Mnz/Aicda⁺ Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ TgTn(sb-T2/Onc2)6070Njen/0	involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J	MGI:4367198
cn2	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ TgTn(sb-T2/Onc2)6070Njen/0	involves: 129 * C57BL/6 * C57BL/6J	MGI:4367197
cn3	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Trp53^tm3Tyj/Trp53⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ TgTn(sb-T2/Onc)68Dla/0	involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N	MGI:3839859
cn4	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Tg(Vil1-cre)20Syr/0 TgTn(sb-T2/Onc)68Dla/0	involves: C57BL/6 * DBA/2 * FVB/N	MGI:3839797
cn5	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Tg(Vil1-cre)20Syr/0 TgTn(sb-T2/Onc)76Dla/0	involves: C57BL/6 * DBA/2 * FVB/N	MGI:3839798
cn6	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ TgTn(sb-T2/Onc)68Dla/0	involves: C57BL/6 * DBA/2 * FVB/N	MGI:3839857

Allelic Composition	Aicda^tm1(cre)Mnz/Aicda⁺ Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background	involves: 129 * 129P2/OlaHsd * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aicda^tm1(cre)Mnz mutation (1 available); any Aicda mutation (55 available)
Gt(ROSA)26Sor^{tm2(sb11)Njen} mutation (7 available); any Gt(ROSA)26Sor mutation (942 available)
TgTn(sb-T2/Onc2)6070Njen mutation (2 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:153656 )

• compared with Gt(ROSA)26Sor^{tm2(sb11)Njen} TgTn(sb-T2/Onc2)6070Njen mice

neoplasm

increased tumor incidence ( J:153656 )

• greater than 90% of moribund mice develop tumors with an average latency of 46 weeks

increased skin squamous cell carcinoma incidence ( J:153656 )

• in one mouse

increased medulloblastoma incidence ( J:153656 )

• in one mouse

increased hemolymphoid system tumor incidence ( J:153656 )

• mice develop hematopoietic tumors including B cell, T cell, and myeloid tumors unlike Gt(ROSA)26Sor^{tm2(sb11)Njen} TgTn(sb-T2/Onc2)6070Njen mice that do not develop tumors

increased T cell derived lymphoma incidence ( J:153656 )

• 3 T cell lymphomas develop

increased leukemia incidence ( J:153656 )

• 2 myeloid leukemia tumors develop

increased B cell derived lymphoma incidence ( J:153656 )

• mice develop B cell lymphomas including diffuse large cell lymphomas and follicular lymphomas

• one mouse developed pre-B lymphoma

increased follicular lymphoma incidence ( J:153656 )

integument

increased skin squamous cell carcinoma incidence ( J:153656 )

• in one mouse

nervous system

increased medulloblastoma incidence ( J:153656 )

• in one mouse

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:153656 )

• 3 T cell lymphomas develop

Allelic Composition	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ TgTn(sb-T2/Onc2)6070Njen/0
Genetic Background	involves: 129 * C57BL/6 * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to infection ( J:153656 )

• 2 mice develop urinary tract infections

liver/biliary system

liver cirrhosis ( J:153656 )

• in one mouse

muscle

muscle degeneration ( J:153656 )

• one mouse exhibited myocyte degeneration

integument

abnormal skin condition ( J:153656 )

• one mouse exhibited skin irritation

Allelic Composition	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Trp53^tm3Tyj/Trp53⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ TgTn(sb-T2/Onc)68Dla/0
Genetic Background	involves: 129S4/SvJae * C57BL/6 * DBA/2 * FVB/N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm2(sb11)Njen} mutation (7 available); any Gt(ROSA)26Sor mutation (942 available)
Speer6-ps1^{Tg(Alb-cre)21Mgn} mutation (6 available); any Speer6-ps1 mutation (4 available)
TgTn(sb-T2/Onc)68Dla mutation (1 available)
Trp53^tm3Tyj mutation (3 available); any Trp53 mutation (232 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:147264 )

• seen in older males

increased liver adenoma incidence ( J:147264 )

• tumor formation is more prevalent and starts earlier in males compared to females

liver/biliary system

abnormal liver morphology ( J:147264 )

• preneoplastic nodules are first detected at about 160 days of age in males

• liver nodules in quadruple transgenic mice are larger and more numerous compared to triple transgenic mice that are wild-type at the Trp53 locus

increased hepatocellular carcinoma incidence ( J:147264 )

• seen in older males

increased liver adenoma incidence ( J:147264 )

• tumor formation is more prevalent and starts earlier in males compared to females

Allelic Composition	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Tg(Vil1-cre)20Syr/0 TgTn(sb-T2/Onc)68Dla/0
Genetic Background	involves: C57BL/6 * DBA/2 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:146887 )

neoplasm

increased gastrointestinal tumor incidence ( J:146887 )

• increased incidence of intraepithelial neoplasias in the small and large intestines

increased small intestine adenocarcinoma incidence ( J:146887 )

increased intestinal adenoma incidence ( J:146887 )

• adenomas are seen in the small and large intestines

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:146887 )

• increased incidence of intraepithelial neoplasias in the small and large intestines

increased small intestine adenocarcinoma incidence ( J:146887 )

increased intestinal adenoma incidence ( J:146887 )

• adenomas are seen in the small and large intestines

Allelic Composition	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Tg(Vil1-cre)20Syr/0 TgTn(sb-T2/Onc)76Dla/0
Genetic Background	involves: C57BL/6 * DBA/2 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

premature death ( J:146887 )

neoplasm

increased gastrointestinal tumor incidence ( J:146887 )

• increased incidence of intraepithelial neoplasias in the small and large intestines

increased small intestine adenocarcinoma incidence ( J:146887 )

increased intestinal adenoma incidence ( J:146887 )

• adenomas are seen in the small and large intestines

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:146887 )

• increased incidence of intraepithelial neoplasias in the small and large intestines

increased small intestine adenocarcinoma incidence ( J:146887 )

increased intestinal adenoma incidence ( J:146887 )

• adenomas are seen in the small and large intestines

Allelic Composition	Gt(ROSA)26Sor^{tm2(sb11)Njen}/Gt(ROSA)26Sor⁺ Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺ TgTn(sb-T2/Onc)68Dla/0
Genetic Background	involves: C57BL/6 * DBA/2 * FVB/N

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased hepatocellular carcinoma incidence ( J:147264 )

• seen in older males

increased liver adenoma incidence ( J:147264 )

• tumor formation is more prevalent and starts earlier in males compared to females

liver/biliary system

abnormal liver morphology ( J:147264 )

• preneoplastic nodules are first detected at about 160 days of age in males

increased hepatocellular carcinoma incidence ( J:147264 )

• seen in older males

increased liver adenoma incidence ( J:147264 )

• tumor formation is more prevalent and starts earlier in males compared to females

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23