Phenotypes associated with this allele
Allelic
Composition |
Snai1tm1.1Stjw/Snai1+
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Genetic
Background |
involves: 129S6/SvEvTac * C57BL/6 * SJL |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snai1tm1.1Stjw mutation
(0 available);
any
Snai1 mutation
(9 available)
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cellular
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• adenovirus cre-treated fibroblasts on a chorioallantoic membrane exhibit reduced ability to induce neovessel formation compared to wild-type cells
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• adenovirus cre-treated fibroblasts exhibit decreased invasiveness of a chorioallantoic membrane compared to wild-type cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snai1tm1.1Stjw mutation
(0 available);
any
Snai1 mutation
(9 available)
Twist2tm1.1(cre)Dor mutation
(1 available);
any
Twist2 mutation
(10 available)
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normal phenotype
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• viable with no gross abnormalities at E14.5 and P1
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Commd10Tg(Vav1-icre)A2Kio mutation
(3 available);
any
Commd10 mutation
(24 available)
Snai1tm1.1Stjw mutation
(0 available);
any
Snai1 mutation
(9 available)
|
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normal phenotype
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• viable with no gross abnormalities at E14.5, E17.5 and P1
• hematopoietic progenitors from E9.5 embryos demonstrate comparable erythroid colony formation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Snai1tm1.1Stjw mutation
(0 available);
any
Snai1 mutation
(9 available)
Tg(Tek-cre)1Ywa mutation
(6 available)
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mortality/aging
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• by E11.5 and E12.5, approximately 50 and 100% of mice die, respectively
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cardiovascular system
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• cranial blood vessels fail to undergo remodeling events
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• decreased vascularization with fewer fetal blood vessels invading
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• cranial blood vessels fail to undergo remodeling events
• at E11.5 about 50% of embryos are necrotic with no intact vascular structures
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• intersomitic vessels form but are unable to organize or full infiltrate the somites, displaying significant decreases in vessel length and branch points
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• impaired vascularization of the tail with the formation of truncated and disorganized networks
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• decrease in the number of mesenchymal cells in the atrioventricular canal
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embryo
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• decreased vascularization with fewer fetal blood vessels invading
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• at E10.5 and E11.5 crown to rump length is decreased by 32 and 47%, respectively, compared to control littermates
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• severely defective remodeling of the primary vascular plexus at E10.5
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growth/size/body
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• at E10.5 and E11.5 crown to rump length is decreased by 32 and 47%, respectively, compared to control littermates
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nervous system
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• cranial blood vessels fail to undergo remodeling events
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Analysis Tools