About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ppp1r15btm1Dron
targeted mutation 1, David Ron
MGI:3833920
Summary 7 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ppp1r15btm1Dron/Ppp1r15btm1Dron involves: 129P2/OlaHsd MGI:3833922
cx2
 		Eif2s1tm1Rjk/Eif2s1+
Ppp1r15btm1Dron/Ppp1r15btm1Dron 		involves: 129P2/OlaHsd MGI:3833923
cx3
 		Eif2s1tm1Rjk/Eif2s1tm1Rjk
Ppp1r15btm1Dron/Ppp1r15btm1Dron 		involves: 129P2/OlaHsd MGI:3833924
cx4
 		Ppp1r15atm1Dron/Ppp1r15atm1Dron
Ppp1r15btm1Dron/Ppp1r15btm1Dron 		involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:3833925
cx5
 		Ppp1r15atm1Dron/Ppp1r15a+
Ppp1r15btm1Dron/Ppp1r15btm1Dron 		involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:3833926
cx6
 		Ppp1r15atm1Dron/Ppp1r15atm1Dron
Ppp1r15btm1Dron/Ppp1r15b+ 		involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:3833927
cx7
 		Eif2s1tm1Rjk/Eif2s1tm1Rjk
Ppp1r15atm1Dron/Ppp1r15atm1Dron
Ppp1r15btm1Dron/Ppp1r15btm1Dron 		involves: 129P2/OlaHsd * 129S6/SvEvTac MGI:3833928


Genotype
MGI:3833922
hm1
Allelic
Composition		 Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r15btm1Dron mutation (0 available); any Ppp1r15b mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Stunted growth of Ppp1r15btm1Dron/Ppp1r15btm1Dron mice

mortality/aging
neonatal lethality, complete penetrance ( J:144954 )
• mice die within the first day of life

hematopoietic system
abnormal erythrocyte morphology ( J:144954 )
• red blood cell size and shape are abnormal
echinocytosis ( J:144954 )
• at E18.5

growth/size/body
decreased birth body size ( J:144954 )
• pups are half the size of wild-type mice at birth

liver/biliary system
abnormal liver morphology ( J:144954 )
• liver morphology is consistent with compensatory proliferation of blood precursors

behavior/neurological
abnormal suckling behavior ( J:144954 )
• mice fail to suckle

integument
pallor ( J:144954 )
• at birth




Genotype
MGI:3833923
cx2
Allelic
Composition		 Eif2s1tm1Rjk/Eif2s1+
Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2s1tm1Rjk mutation (1 available); any Eif2s1 mutation (57 available)
Ppp1r15btm1Dron mutation (0 available); any Ppp1r15b mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased fetal weight ( J:144954 )
• at E18.5

hematopoietic system




Genotype
MGI:3833924
cx3
Allelic
Composition		 Eif2s1tm1Rjk/Eif2s1tm1Rjk
Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic
Background		 involves: 129P2/OlaHsd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2s1tm1Rjk mutation (1 available); any Eif2s1 mutation (57 available)
Ppp1r15btm1Dron mutation (0 available); any Ppp1r15b mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:144954 )
• mice die after birth due to hypoglycemia

hematopoietic system
decreased erythrocyte cell number ( J:144954 )
• at E18.5, red blood cell counts are less than in wild-type mice but greater than in Ppp1r15btm1Dron homozygotes

growth/size/body
decreased fetal weight ( J:144954 )
• at E18.5, weight is less than in wild-type mice but greater than in Ppp1r15btm1Dron homozygotes

homeostasis/metabolism




Genotype
MGI:3833925
cx4
Allelic
Composition		 Ppp1r15atm1Dron/Ppp1r15atm1Dron
Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r15atm1Dron mutation (0 available); any Ppp1r15a mutation (23 available)
Ppp1r15btm1Dron mutation (0 available); any Ppp1r15b mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Ppp1r15atm1Dron/Ppp1r15atm1Dron Ppp1r15btm1Dron/Ppp1r15btm1Dron embryos fail to develop past the preimplantation period

mortality/aging
embryonic lethality before implantation, complete penetrance ( J:144954 )
• embryos do not develop beyond pre-implantation stages




Genotype
MGI:3833926
cx5
Allelic
Composition		 Ppp1r15atm1Dron/Ppp1r15a+
Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r15atm1Dron mutation (0 available); any Ppp1r15a mutation (23 available)
Ppp1r15btm1Dron mutation (0 available); any Ppp1r15b mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:3833927
cx6
Allelic
Composition		 Ppp1r15atm1Dron/Ppp1r15atm1Dron
Ppp1r15btm1Dron/Ppp1r15b+
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppp1r15atm1Dron mutation (0 available); any Ppp1r15a mutation (23 available)
Ppp1r15btm1Dron mutation (0 available); any Ppp1r15b mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:144954 )
N
• mice survive into adulthood




Genotype
MGI:3833928
cx7
Allelic
Composition		 Eif2s1tm1Rjk/Eif2s1tm1Rjk
Ppp1r15atm1Dron/Ppp1r15atm1Dron
Ppp1r15btm1Dron/Ppp1r15btm1Dron
Genetic
Background		 involves: 129P2/OlaHsd * 129S6/SvEvTac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Eif2s1tm1Rjk mutation (1 available); any Eif2s1 mutation (57 available)
Ppp1r15atm1Dron mutation (0 available); any Ppp1r15a mutation (23 available)
Ppp1r15btm1Dron mutation (0 available); any Ppp1r15b mutation (15 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:144954 )
N
• mice survive until E17.5

growth/size/body
growth/size/body region phenotype ( J:144954 )
N
• unlike Ppp1r15btm1Dron homozygotes, mice are of normal size at E17.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory