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Allele Symbol Allele Name Allele ID |
Supv3l1tm2Jkl targeted mutation 2, Jan Klysik MGI:3833740 |
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| Summary |
3 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Kyphosis and scaling on feet develop in Supv3l1tm2Jkl/Supv3l1tm2Jkl Tg(CAG-cre/Esr1*)5Amc/0 mice following tamoxifen treatment
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• mice die by 15 weeks of age
• tamoxifen-treated mice die by 6 weeks of age
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• in the lungs in tamoxifen-treated mice
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• mice exhibit thymic atrophy that develops more rapidly in tamoxifen treated mice
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• 6-fold in tamoxifen-treated mice compared to mice heterozygous for the floxed allele
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• tamoxifen-treated mice exhibit decreased DN2, DN3, and DN4 cells compared to mice heterozygous for the floxed allele
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• in tamoxifen-treated mice
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• more than 10-fold in tamoxifen-treated mice
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• in tamoxifen-treated mice
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• in tamoxifen-treated mice
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• chronic and acute in untreated and tamoxifen-treated mice
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• in tamoxifen-treated mice
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• mice exhibit adipose tissue loss that develops more rapidly in tamoxifen treated mice
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• chronic and acute in untreated and tamoxifen-treated mice
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• thickened in in tamoxifen-treated mice and untreated mice
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• mice exhibit sarcopenia atrophy that develops more rapidly in tamoxifen treated mice
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• mice exhibit thymic atrophy that develops more rapidly in tamoxifen treated mice
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• 6-fold in tamoxifen-treated mice compared to mice heterozygous for the floxed allele
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• in tamoxifen-treated mice, the numbers of sebaceous glands is reduced compared to in untreated mice
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• tamoxifen-treated mice exhibit focal vascular ectasia in the skin unlike in untreated mice
• mice treated topically with tamoxifen exhibit dilated vasculature at the site of application
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• locomotor functions fail in moribund mice
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• tamoxifen-treated mice exhibit an increase in apoptosis compared to untreated mice
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• in the lungs in tamoxifen-treated mice
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• mice exhibit thymic atrophy that develops more rapidly in tamoxifen treated mice
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• 6-fold in tamoxifen-treated mice compared to mice heterozygous for the floxed allele
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• tamoxifen-treated mice exhibit decreased DN2, DN3, and DN4 cells compared to mice heterozygous for the floxed allele
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• in tamoxifen-treated mice
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• more than 10-fold in tamoxifen-treated mice
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• in tamoxifen-treated mice
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• in tamoxifen-treated mice
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• in the lungs in tamoxifen-treated mice
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| N |
• unlike in Supv3l1tm2Jkl/Supv3l1tm2Jkl floxed Tg(Mx1-cre)1Cgn mice, tamoxifen-treated mice exhibit normal hair growth
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• mice exhibit adipose tissue loss that develops more rapidly in tamoxifen treated mice
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• in tamoxifen-treated mice, the numbers of sebaceous glands is reduced compared to in untreated mice
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• tamoxifen treated mice exhibit focal vascular ectasia, reduced adipose tissue, and atrophic muscle layer in the skin unlike in untreated mice
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• apoptosis rates in the basal layer are increased in tamoxifen-treated mice compared to in untreated mice
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• mild in tamoxifen-treated mice and at the site of application in mice treated topically with tamoxifen
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• at the site of tamoxifen application when applied directly to the skin
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• hypergranulosis develops in tamoxifen-treated mice and at the site of application in mice treated topically with tamoxifen
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• in tamoxifen-treated mice
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• in tamoxifen-treated mice and at the site of tamoxifen application when applied directly to the skin
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• at the site of tamoxifen application when applied directly to the skin
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• on the skin and tails of tamoxifen-treated mice and at the site of tamoxifen application when applied directly to the skin
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Disfigured ears, abdominal alopecia and scales on feet in Supv3l1tm2Jkl/Supv3l1tm2Jkl Tg(Mx1-cre)1Cgn/0 mice
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• some mice become moribund at 4 weeks of age while others live up to 10 weeks
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• in the red pulp of the liver
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• in the red pulp of the liver
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• 50% of wild-type at 4 weeks
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• at weaning, mice exhibit slower growth than wild-type mice
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• in moribund mice
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• mice exhibit a thickened interstitium with infiltration by inflammatory cells and occasionally foamy macrophages
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• in moribund mice
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• the number of sebaceous glands is decreased compared to in wild-type mice
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• dilated vessels are found in the dermal layer of cells of the ear unlike in wild-type mice
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• locomotor functions fail in moribund mice
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• at weaning mice have flattened and disfigured ears compared to in wild-type mice
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• in the red pulp of the liver
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• in the red pulp of the liver
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• in the red pulp of the liver
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• the number of sebaceous glands is decreased compared to in wild-type mice
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• at weaning, mice exhibit abnormal appearance and density of coat hairs compared to in wild-type mice
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• some mice exhibit mild dermal acute inflammatory infiltrate unlike in wild-type mice
• the dermal layer is atrophic unlike in wild-type mice
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• dyskeratosis (apoptosis) is increased in the basal cell layer and mid-epidermis compared to in wild-type mice
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• severe
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• on the dorsal and abdominal skin
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• after 6 weeks mice exhibit scaly dorsal and abdominal skin, feet, tail, and ears
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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