All Phenotypes Rad50<tm3Jpt> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Rad50^tm3Jpt
targeted mutation 3, John H J Petrini
MGI:3832533

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ Rad50^tm3Jpt/Rad50^tm4.1Jpt	involves: 129/Sv * C57BL/6	MGI:5614075
cn2	Rad50^tm1Jpt/Rad50^tm3Jpt Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺	involves: 129/Sv * C57BL/6	MGI:5614076
cn3	Rad50^tm1Jpt/Rad50^tm3Jpt Tg(Pcp2-cre)2Mpin/0	involves: 129S7/SvEvBrd * C57BL/6	MGI:3832543
cn4	Rad50^tm1Jpt/Rad50^tm3Jpt Tg(Mx1-cre)1Cgn/0	involves: 129S7/SvEvBrd * C57BL/6 * CBA	MGI:3832542

Allelic Composition	Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺ Rad50^tm3Jpt/Rad50^tm4.1Jpt
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj} mutation (6 available); any Gt(ROSA)26Sor mutation (1046 available)
Rad50^tm3Jpt mutation (1 available); any Rad50 mutation (53 available)
Rad50^tm4.1Jpt mutation (0 available); any Rad50 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:209141 )

• tamoxifen treated mice do not live beyond 2 weeks of age due to intestinal failure

digestive/alimentary system

abnormal intestine morphology ( J:209141 )

• intestinal defects are seen by day 9 of tamoxifen treatment

• die of intestinal failure

Allelic Composition	Rad50^tm1Jpt/Rad50^tm3Jpt Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj}/Gt(ROSA)26Sor⁺
Genetic Background	involves: 129/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm1(cre/ERT2)Tyj} mutation (6 available); any Gt(ROSA)26Sor mutation (1046 available)
Rad50^tm1Jpt mutation (1 available); any Rad50 mutation (53 available)
Rad50^tm3Jpt mutation (1 available); any Rad50 mutation (53 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:209141 )

• tamoxifen treated mice do not live beyond 2 weeks of age due to intestinal failure

digestive/alimentary system

abnormal intestine morphology ( J:209141 )

• intestinal defects are seen by day 9 of tamoxifen treatment

• die of intestinal failure

Allelic Composition	Rad50^tm1Jpt/Rad50^tm3Jpt Tg(Pcp2-cre)2Mpin/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rad50^tm1Jpt mutation (1 available); any Rad50 mutation (53 available)
Rad50^tm3Jpt mutation (1 available); any Rad50 mutation (53 available)
Tg(Pcp2-cre)2Mpin mutation (1 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

behavior/neurological

abnormal gait ( J:144766 )

• minor

nervous system

nervous system phenotype ( J:144766 )

N	• mice exhibit normal nervous system morphology with no increase in DNA damage

Allelic Composition	Rad50^tm1Jpt/Rad50^tm3Jpt Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129S7/SvEvBrd * C57BL/6 * CBA

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

liver/biliary system

decreased hepatocyte proliferation ( J:144766 )

• following partial hepatectomy, proliferation of pIpC-treated hepatocyte is decreased compared to in wild-type mice due to accumulation of DNA damage

• however, a subset of hepatocytes resolve their DNA damage and divide

abnormal hepatocyte morphology ( J:144766 )

• while liver regeneration following partial hepatectomy is normal, pIpC-treated hepatocytes exhibit an increase in DNA damage compared to wild-type cells

• however, a subset of hepatocytes resolve their DNA damage and divide

liver hypoplasia ( J:144766 )

• following partial hepatectomy, pIpC-treated livers exhibit reduced cellularity and endoreduplication compared to in similarly-treated wild-type mice

hematopoietic system

decreased bone marrow cell number ( J:144766 )

• the only viable bone marrow left after treatment with pIpC fails to exhibit recombination

cellular

decreased hepatocyte proliferation ( J:144766 )

• following partial hepatectomy, proliferation of pIpC-treated hepatocyte is decreased compared to in wild-type mice due to accumulation of DNA damage

• however, a subset of hepatocytes resolve their DNA damage and divide

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