Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(cre/ERT2)Tyj mutation
(3 available);
any
Gt(ROSA)26Sor mutation
(942 available)
Rad50tm3Jpt mutation
(1 available);
any
Rad50 mutation
(53 available)
Rad50tm4.1Jpt mutation
(0 available);
any
Rad50 mutation
(53 available)
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mortality/aging
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• tamoxifen treated mice do not live beyond 2 weeks of age due to intestinal failure
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digestive/alimentary system
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• intestinal defects are seen by day 9 of tamoxifen treatment
• die of intestinal failure
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mortality/aging
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• tamoxifen treated mice do not live beyond 2 weeks of age due to intestinal failure
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digestive/alimentary system
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• intestinal defects are seen by day 9 of tamoxifen treatment
• die of intestinal failure
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behavior/neurological
nervous system
N |
• mice exhibit normal nervous system morphology with no increase in DNA damage
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liver/biliary system
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• following partial hepatectomy, proliferation of pIpC-treated hepatocyte is decreased compared to in wild-type mice due to accumulation of DNA damage
• however, a subset of hepatocytes resolve their DNA damage and divide
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• while liver regeneration following partial hepatectomy is normal, pIpC-treated hepatocytes exhibit an increase in DNA damage compared to wild-type cells
• however, a subset of hepatocytes resolve their DNA damage and divide
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• following partial hepatectomy, pIpC-treated livers exhibit reduced cellularity and endoreduplication compared to in similarly-treated wild-type mice
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hematopoietic system
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• the only viable bone marrow left after treatment with pIpC fails to exhibit recombination
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cellular
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• following partial hepatectomy, proliferation of pIpC-treated hepatocyte is decreased compared to in wild-type mice due to accumulation of DNA damage
• however, a subset of hepatocytes resolve their DNA damage and divide
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