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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Xrcc2tm2Pmc
targeted mutation 2, Peter J McKinnon
MGI:3831320
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Trp53tm1Tyj/Trp53tm1Tyj
Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0 		involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL MGI:3831338
cn2
 		Lig4tm1Pmc/Lig4tm1Pmc
Trp53tm1Tyj/Trp53tm1Tyj
Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0 		involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL MGI:3831351
cn3
 		Lig4tm1Pmc/Lig4tm1Pmc
Trp53tm1Tyj/Trp53+
Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0 		involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL MGI:3831355
cn4
 		Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0 		involves: 129S1/Sv * C57BL/6 * SJL MGI:3831335


Genotype
MGI:3831338
cn1
Allelic
Composition		 Trp53tm1Tyj/Trp53tm1Tyj
Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
Xrcc2tm2Pmc mutation (0 available); any Xrcc2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:144617 )
• mice die by 28 weeks unlike Xrcc2tm2Pmc/Xrcc2tm2Pmc Tg(Nes-cre)1Kln mice with wild-type Trp53

neoplasm
increased medulloblastoma incidence ( J:144617 )
• 100% of mice develop medulloblastoma beginning at 16 weeks

nervous system
increased medulloblastoma incidence ( J:144617 )
• 100% of mice develop medulloblastoma beginning at 16 weeks




Genotype
MGI:3831351
cn2
Allelic
Composition		 Lig4tm1Pmc/Lig4tm1Pmc
Trp53tm1Tyj/Trp53tm1Tyj
Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm1Pmc mutation (0 available); any Lig4 mutation (44 available)
Tg(Nes-cre)1Kln mutation (4 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
Xrcc2tm2Pmc mutation (0 available); any Xrcc2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:144617 )
• mice die by 16 weeks

neoplasm
increased medulloblastoma incidence ( J:144617 )
• 100% of mice develop medulloblastoma beginning at 14 weeks

nervous system
increased medulloblastoma incidence ( J:144617 )
• 100% of mice develop medulloblastoma beginning at 14 weeks




Genotype
MGI:3831355
cn3
Allelic
Composition		 Lig4tm1Pmc/Lig4tm1Pmc
Trp53tm1Tyj/Trp53+
Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/Sv * 129S2/SvPas * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lig4tm1Pmc mutation (0 available); any Lig4 mutation (44 available)
Tg(Nes-cre)1Kln mutation (4 available)
Trp53tm1Tyj mutation (12 available); any Trp53 mutation (232 available)
Xrcc2tm2Pmc mutation (0 available); any Xrcc2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:144617 )
• mice die by 32 weeks

neoplasm
abnormal tumor morphology ( J:144617 )
• tumors exhibit a loss of heterozygosity at the Trp53 gene
increased medulloblastoma incidence ( J:144617 )
• 75% of mice develop medulloblastoma beginning at 23 weeks

nervous system
increased medulloblastoma incidence ( J:144617 )
• 75% of mice develop medulloblastoma beginning at 23 weeks




Genotype
MGI:3831335
cn4
Allelic
Composition		 Xrcc2tm2Pmc/Xrcc2tm2Pmc
Tg(Nes-cre)1Kln/0
Genetic
Background		 involves: 129S1/Sv * C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Nes-cre)1Kln mutation (4 available)
Xrcc2tm2Pmc mutation (0 available); any Xrcc2 mutation (17 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:144617 )
N
• compared to germ line deletions of this gene, mice exhibit no increase in apoptosis during neural development




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory