Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccr6tm1Gma mutation
(3 available);
any
Ccr6 mutation
(36 available)
Tg(Rorc-EGFP)1Ebe mutation
(0 available)
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immune system
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• splenic Th-17 cells that have an alphabeta TCR and are GFP-positive are significantly increased compared to controls
• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly increased
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hematopoietic system
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• splenic Th-17 cells that have an alphabeta TCR and are GFP-positive are significantly increased compared to controls
• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly increased
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il12rb1tm1Jm mutation
(2 available);
any
Il12rb1 mutation
(35 available)
Tg(Rorc-EGFP)1Ebe mutation
(0 available)
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hematopoietic system
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• splenic Th-17 cells that have an alphabeta TCR and are GFP-positive are slightly decreased compared to controls
• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly decreased
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immune system
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• splenic Th-17 cells that have an alphabeta TCR and are GFP-positive are slightly decreased compared to controls
• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly decreased
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il6tm1Kopf mutation
(9 available);
any
Il6 mutation
(37 available)
Tg(Rorc-EGFP)1Ebe mutation
(0 available)
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hematopoietic system
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• splenic Th-17 cells that have alphabeta TCR and are GFP-positive are decreased by half compared to controls
• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly decreased
• numbers of Th17 gammadelta T cells are normal
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immune system
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• splenic Th-17 cells that have alphabeta TCR and are GFP-positive are decreased by half compared to controls
• the ratio of IL-17 producing cells to IL-10 producing cells among the GFP-positive T cell population is significantly decreased
• numbers of Th17 gammadelta T cells are normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Foxp3sf mutation
(5 available);
any
Foxp3 mutation
(55 available)
Tg(Rorc-EGFP)1Ebe mutation
(0 available)
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hematopoietic system
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• mutant bone marrow cells fail to generate IL-10 producing T cells and generates only a reduced proportion of IL-17-producing T cells when marrow cells are transferred into irradiated wild-type hosts
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immune system
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• mutant bone marrow cells fail to generate IL-10 producing T cells and generates only a reduced proportion of IL-17-producing T cells when marrow cells are transferred into irradiated wild-type hosts
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
ApcMin mutation
(12 available);
any
Apc mutation
(154 available)
Tg(Rorc-EGFP)1Ebe mutation
(0 available)
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immune system
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• in the mesenteric lymph node (MLN), the ratio of IL-17 producing cells to Foxp3-positive cells within the GFP-positive T cell population is significantly decreased compared to controls
• this observation is compared to an induced-colitis control where ratio of the two effector cell populations remain the same in the MLN despite inflammation occuring
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• mesenteric lymph nodes are hyperplastic
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• mesenteric lymph nodes are hyperplastic
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digestive/alimentary system
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• ileal polyps occur in these mice
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hematopoietic system
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• in the mesenteric lymph node (MLN), the ratio of IL-17 producing cells to Foxp3-positive cells within the GFP-positive T cell population is significantly decreased compared to controls
• this observation is compared to an induced-colitis control where ratio of the two effector cell populations remain the same in the MLN despite inflammation occuring
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Analysis Tools