Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2ctm1Knk mutation
(1 available);
any
Htr2c mutation
(12 available)
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mortality/aging
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• less than 20% of mice survive the postnatal period
• however, removal of competing wild-type and female heterozygous littermates increases survival to 80%
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growth/size/body
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• despite normal birth weights, mice exhibit a 50% reduction in body weight gain compared to wild-type mice regardless of strain background or fostering with wild-type mothers
• however, between 3 and 5 weeks of age growth rates are normal
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• mice exhibit decreased body length compared to wild-type mice but this difference becomes less significant after weaning
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2ctm1Knk mutation
(1 available);
any
Htr2c mutation
(12 available)
|
|
|
growth/size/body
|
• despite normal birth weights, mice exhibit a 50% reduction in body weight gain compared to wild-type mice regardless of strain background or fostering with wild-type mothers
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2ctm1Knk mutation
(1 available);
any
Htr2c mutation
(12 available)
|
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behavior/neurological
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• mice exhibit hyperphagia
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growth/size/body
N |
• unlike when either gene is knocked-out, mice exhibit normal growth rates
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• at 6 weeks but not 16 weeks
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|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2ctm1Knk mutation
(1 available);
any
Htr2c mutation
(12 available)
|
|
|
mortality/aging
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• mice exhibit convulsions and death at a dose of MK212 (a HTR2C-selective agonist) that is 100 times lower than in wild-type mice
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• less than 20% of mice survive the postnatal period
• however, removal of competing wild-type and female heterozygous littermates increases survival to 80%
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homeostasis/metabolism
growth/size/body
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• adipose accumulation is lower than in wild-type mice
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• mice exhibit decreased body length compared to wild-type mice but this difference becomes less significant after weaning
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• postnatal growth retardation is not rescued by injection of growth hormone
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• despite normal birth weights, mice exhibit a 50% reduction in body weight gain compared to wild-type mice regardless of strain background or fostering with wild-type mothers
• however, between 3 and 5 weeks of age growth rates are normal
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behavior/neurological
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• low doses of MK212 result in more pronounced hypoactivity than in wild-type mice, and food intake can be decreased by treatment with MK212 or mCPP
• low doses of SB242084, but not ketanserin or SB204741 (all HTR2C-specific antagonists) induce more hypolocomotion than in wild-type mice that cannot be reverted by treatment with haloperidol (a D2, D3 and D4 dopamine receptor antagonist) or R(+)-SCH23390 (a D1 dopamine receptor antagonist)
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• mice exhibit hyperphagia
• however, food intake can be decreased by treatment with MK212
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• mice are 2-fold less active than wild-type mice
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adipose tissue
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• adipose accumulation is lower than in wild-type mice
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Htr2ctm1Knk mutation
(1 available);
any
Htr2c mutation
(12 available)
|
|
|
growth/size/body
|
• despite normal birth weights, mice exhibit a 50% reduction in body weight gain compared to wild-type mice regardless of strain background or fostering with wild-type mothers
|