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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(SERPINA1-cre)1Arge
transgene insertion 1, Argiris Efstratiadis
MGI:3821757
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Ccar2tm1Dac/Ccar2tm1Dac
Sirt1tm1Ygu/Sirt1tm1Ygu
Tg(SERPINA1-cre)1Arge/0 		involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J MGI:5804112
cn2
 		Igf1tm2Arge/Igf1tm2Arge
Tg(SERPINA1-cre)1Arge/0 		involves: 129S/SvEv * C57BL/6J MGI:3821761
cn3
 		Igf1tm2Arge/Igf1tm2.1Arge
Tg(SERPINA1-cre)1Arge/0 		involves: 129S/SvEv * C57BL/6J * CBA MGI:3821763


Genotype
MGI:5804112
cn1
Allelic
Composition		 Ccar2tm1Dac/Ccar2tm1Dac
Sirt1tm1Ygu/Sirt1tm1Ygu
Tg(SERPINA1-cre)1Arge/0
Genetic
Background		 involves: 129 * 129S1/Sv * 129X1/SvJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ccar2tm1Dac mutation (0 available); any Ccar2 mutation (37 available)
Sirt1tm1Ygu mutation (2 available); any Sirt1 mutation (78 available)
Tg(SERPINA1-cre)1Arge mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:228688 )
N
• normal body weight and fat content
decreased susceptibility to diet-induced obesity ( J:228688 )
• mice fed a high-fat diet gain less weight than controls and show no increase in body fat

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:228688 )
N
• normal glucose tolerance
decreased susceptibility to diet-induced obesity ( J:228688 )
• mice fed a high-fat diet gain less weight than controls and show no increase in body fat




Genotype
MGI:3821761
cn2
Allelic
Composition		 Igf1tm2Arge/Igf1tm2Arge
Tg(SERPINA1-cre)1Arge/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1tm2Arge mutation (0 available); any Igf1 mutation (27 available)
Tg(SERPINA1-cre)1Arge mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
decreased survivor rate ( J:142247 )
• only 11% of neonates survive
neonatal lethality, incomplete penetrance ( J:142247 )
• only 11% of neonates survive

reproductive system
reproductive system phenotype ( J:142247 )
N
• unlike Igf1tm2Arge homozygotes, mice are fertile

growth/size/body
decreased body weight ( J:142247 )
• mice weigh 50% of wild-type

homeostasis/metabolism
decreased circulating insulin-like growth factor I level ( J:142247 )
• at E18.5, IGF1 serum levels are below detectable levels
• at P72, IGF1 serum levels are 44% of normal




Genotype
MGI:3821763
cn3
Allelic
Composition		 Igf1tm2Arge/Igf1tm2.1Arge
Tg(SERPINA1-cre)1Arge/0
Genetic
Background		 involves: 129S/SvEv * C57BL/6J * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Igf1tm2.1Arge mutation (0 available); any Igf1 mutation (27 available)
Igf1tm2Arge mutation (0 available); any Igf1 mutation (27 available)
Tg(SERPINA1-cre)1Arge mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:142247 )
• mice weigh 61% of wild-type

homeostasis/metabolism
decreased circulating insulin-like growth factor I level ( J:142247 )
• at E18.5, IGF1 serum levels are 24% of normal
• at P72, IGF1 serum levels are 60% of normal




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/28/2024
MGI 6.13 		The Jackson Laboratory