Analysis Tools|
Allele Symbol Allele Name Allele ID |
Pak6tm1Amin targeted mutation 1, Audrey Minden MGI:3821622 |
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| Summary |
2 genotypes
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
| N |
• despite locomotor deficits, mice exhibit normal balance, coordination and anxiety levels
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• mice exhibit reduced learning of active avoidance behaviors in a T-maze test compared to wild-type mice
• in a T-maze mice exhibit longer avoidance time than wild-type mice
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• mice perform worse than wild-type mice in a passive avoidance T-maze test and exhibit increased time to make the incorrect response compared to wild-type mice
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• mice fail to exhibit an increase in locomotor activity when exposed to a novel environment
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• when exposed to a male intruder, male mice initiate fewer attacks and exhibit increased latency to attack compared to wild-type mice
• however, serotonine and dopamine levels are normal
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• mice exhibit reduced grip strength compared to wild-type mice
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• mice exhibit reduced locomotion in new and familiar environments compared to wild-type mice
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| N |
• mice exhibit normal brain morphology and levels of serotonine and dopamine are normal
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• neurons have smaller growth cones with reduced widths compare to wild-type growth cones and they extend along the shaft unlike growth cones
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• young and old cultured neurons have fewer, shorter neurites than wild-type neurons
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| N |
• mice are fertile and male mice exhibit normal testes morphology
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 09/30/2025 MGI 6.24 |
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