All Phenotypes Kmt2a<tm1Saam> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Kmt2a^tm1Saam
targeted mutation 1, Scott A Armstrong
MGI:3814567

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Kmt2a^tm1Saam/Kmt2a⁺	involves: 129S1/Sv * C57BL/6	MGI:3814578
cn2	Kmt2a^tm1Saam/Kmt2a⁺ Tg(Mx1-cre)1Cgn/0	involves: 129S1/Sv * C57BL/6 * CBA	MGI:3814579

Allelic Composition	Kmt2a^tm1Saam/Kmt2a⁺
Genetic Background	involves: 129S1/Sv * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2a^tm1Saam mutation (0 available); any Kmt2a mutation (135 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:140628 )

• born at slightly less than Mendelian frequency

Allelic Composition	Kmt2a^tm1Saam/Kmt2a⁺ Tg(Mx1-cre)1Cgn/0
Genetic Background	involves: 129S1/Sv * C57BL/6 * CBA

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Kmt2a^tm1Saam mutation (0 available); any Kmt2a mutation (135 available)
Tg(Mx1-cre)1Cgn mutation (7 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

neoplasm

increased leukemia incidence ( J:140628 )

• following pIpC treatment 14 of 22 mice developed acute leukemia

• median latency for leukemia development was 131 days

• infiltration of the bone marrow, spleen and liver with immature hematopoietic cells is seen in moribund mice

• mice may develop either acute myeloid leukemia or acute lymphoblastic leukemia

• gene expression profiles in mice with acute lymphoblastic leukemia recapitulate gene expression profiles seen in human acute lymphoid leukemia

Mouse Models of Human Disease	DO ID	OMIM ID(s)	Ref(s)
acute lymphoblastic leukemia	DOID:9952	OMIM:247640 OMIM:613065	J:140628
acute myeloid leukemia	DOID:9119	OMIM:601626	J:140628

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/30/2024 MGI 6.23