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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tg(Foxn1-cre)8Ghr
transgene insertion 8, Georg A Hollander
MGI:3806589
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Smad4tm2.1Cxd/Smad4tm2.1Cxd
Tg(Foxn1-cre)8Ghr/0 		B6.Cg-Smad4tm2.1Cxd Tg(Foxn1-cre)8Ghr MGI:3810117
cn2
 		Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Tg(Foxn1-cre)8Ghr/0 		involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2 MGI:6112651
cn3
 		Dll4tm1Kaho/Dll4tm1Kaho
Tg(Foxn1-cre)8Ghr/0 		involves: C57BL/6 * DBA/2 MGI:3828486


Genotype
MGI:3810117
cn1
Allelic
Composition		 Smad4tm2.1Cxd/Smad4tm2.1Cxd
Tg(Foxn1-cre)8Ghr/0
Genetic
Background		 B6.Cg-Smad4tm2.1Cxd Tg(Foxn1-cre)8Ghr
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Smad4tm2.1Cxd mutation (2 available); any Smad4 mutation (43 available)
Tg(Foxn1-cre)8Ghr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
small thymus ( J:138837 )
• mice exhibit small thymus
• however, the cellularity and histology of the thymus are normal
abnormal thymus physiology ( J:138837 )
• unlike in wild type mice, the thymus is resistant to increased cellularity induced by KGF

hematopoietic system
small thymus ( J:138837 )
• mice exhibit small thymus
• however, the cellularity and histology of the thymus are normal
abnormal thymus physiology ( J:138837 )
• unlike in wild type mice, the thymus is resistant to increased cellularity induced by KGF

endocrine/exocrine glands
small thymus ( J:138837 )
• mice exhibit small thymus
• however, the cellularity and histology of the thymus are normal
abnormal thymus physiology ( J:138837 )
• unlike in wild type mice, the thymus is resistant to increased cellularity induced by KGF




Genotype
MGI:6112651
cn2
Allelic
Composition		 Slc39a10tm1.1Tfk/Slc39a10tm1.1Tfk
Tg(Foxn1-cre)8Ghr/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Slc39a10tm1.1Tfk mutation (0 available); any Slc39a10 mutation (49 available)
Tg(Foxn1-cre)8Ghr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system

endocrine/exocrine glands

hematopoietic system

cellular




Genotype
MGI:3828486
cn3
Allelic
Composition		 Dll4tm1Kaho/Dll4tm1Kaho
Tg(Foxn1-cre)8Ghr/0
Genetic
Background		 involves: C57BL/6 * DBA/2
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dll4tm1Kaho mutation (0 available); any Dll4 mutation (26 available)
Tg(Foxn1-cre)8Ghr mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
thymus hypoplasia ( J:143473 )
• the thymus contains one third to one twenty-fifth the number of cells as in Dll4tm1Kaho homozygous controls
abnormal lymphopoiesis ( J:143473 )
• double negative 1 (DN1) cells present in the thymus do not develop into T cells but instead differentiate into immature B cell phenotype
• however, differentiation of wild-type hematopoietic progenitor cells transfected with an active form of Notch1 occurs when they are co-culture of thymic lobes lacking Dll4 expression
decreased double-positive T cell number ( J:143473 )
• thymi are populated by double negative cells that do not express Thy1 or TCR instead of double positive and single positive cells found in Dll4tm1Kaho homozygous controls
absent CD4-positive, alpha-beta T cells ( J:143473 )
• thymi are populated by double negative cells that do not express Thy1 or TCR instead of double positive and single positive cells found in Dll4tm1Kaho homozygous controls
absent CD8-positive, alpha-beta T cells ( J:143473 )
• thymi are populated by double negative cells that do not express Thy1 or TCR instead of double positive and single positive cells found in Dll4tm1Kaho homozygous controls

hematopoietic system
thymus hypoplasia ( J:143473 )
• the thymus contains one third to one twenty-fifth the number of cells as in Dll4tm1Kaho homozygous controls
abnormal lymphopoiesis ( J:143473 )
• double negative 1 (DN1) cells present in the thymus do not develop into T cells but instead differentiate into immature B cell phenotype
• however, differentiation of wild-type hematopoietic progenitor cells transfected with an active form of Notch1 occurs when they are co-culture of thymic lobes lacking Dll4 expression
decreased double-positive T cell number ( J:143473 )
• thymi are populated by double negative cells that do not express Thy1 or TCR instead of double positive and single positive cells found in Dll4tm1Kaho homozygous controls
absent CD4-positive, alpha-beta T cells ( J:143473 )
• thymi are populated by double negative cells that do not express Thy1 or TCR instead of double positive and single positive cells found in Dll4tm1Kaho homozygous controls
absent CD8-positive, alpha-beta T cells ( J:143473 )
• thymi are populated by double negative cells that do not express Thy1 or TCR instead of double positive and single positive cells found in Dll4tm1Kaho homozygous controls

endocrine/exocrine glands
thymus hypoplasia ( J:143473 )
• the thymus contains one third to one twenty-fifth the number of cells as in Dll4tm1Kaho homozygous controls




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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory