Dll4^tm1Kaho
Targeted Allele Detail

Summary

• Symbol: Dll4^tm1Kaho
• Name: delta like canonical Notch ligand 4; targeted mutation 1, Katsuto Hozumi
• MGI ID: MGI:3828459
• Synonyms: Dll4^lox
• Gene: Dll4 Location: Chr2:119156265-119166147 bp, + strand Genetic Position: Chr2, 59.97 cM, cytoband E3
• Alliance: Dll4^tm1Kaho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:143473
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A loxP site was inserted into the untranslated region of exon 1 and a floxed neo cassette was inserted downstream of exon 3. Transient cre expression in ES cells was used to remove the neo cassette leaving most of exon 1 through exon 3 floxed. (J:143473)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dll4 Mutation: 26 strains or lines available

References

• Original: J:143473 Hozumi K, et al., Delta-like 4 is indispensable in thymic environment specific for T cell development. J Exp Med. 2008 Oct 27;205(11):2507-13
• All: 12 reference(s)