Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam15tm1Dgen mutation
(0 available);
any
Adam15 mutation
(36 available)
Tg(RHO-VEGFA)V-6Camp mutation
(0 available)
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cardiovascular system
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• reduction in subretinal neovascularization compared to transgenic littermates wild-type for Adam15
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vision/eye
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• reduction in subretinal neovascularization compared to transgenic littermates wild-type for Adam15
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos2tm1Lau mutation
(8 available);
any
Nos2 mutation
(66 available)
Tg(RHO-VEGFA)V-6Camp mutation
(0 available)
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cardiovascular system
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• compared to mice carrying Tg(RHO-VEGFA)V-6Camp and heterozygous for Nos2tm1Lau neovascularization of the retina is significantly reduced
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos3tm1Plh mutation
(1 available);
any
Nos3 mutation
(56 available)
Tg(RHO-VEGFA)V-6Camp mutation
(0 available)
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cardiovascular system
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• compared to mice carrying Tg(RHO-VEGFA)V-6Camp and heterozygous for Nos3tm1Plh neovascularization of the retina is significantly reduced
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nos1tm1Plh mutation
(3 available);
any
Nos1 mutation
(82 available)
Tg(RHO-VEGFA)V-6Camp mutation
(0 available)
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cardiovascular system
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• compared to mice carrying Tg(RHO-VEGFA)V-6Camp and heterozygous for Nos1tm1Plh neovascularization of the retina is significantly reduced
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
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cardiovascular system
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• focal areas of intraretinal and subretinal neovascularization are seen at 1 month of age
(J:41411)
• blood vessels extend from the inner nuclear layer through the outer nuclear layer and form small networks of vessels in the outer segment layer
(J:41411)
• at 3 months of age, vessels extend down from the inner nuclear layer to form a large plexus of vessels in the subretinal space
(J:41411)
• in some cases vessel lumens and cavities within the plexus contain retinal pigment epithelial cells
(J:41411)
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• at 1, 3, and 4 months of age leakage is detected in the retinal vasculature
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vision/eye
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• focal areas of intraretinal and subretinal neovascularization are seen at 1 month of age
(J:41411)
• blood vessels extend from the inner nuclear layer through the outer nuclear layer and form small networks of vessels in the outer segment layer
(J:41411)
• at 3 months of age, vessels extend down from the inner nuclear layer to form a large plexus of vessels in the subretinal space
(J:41411)
• in some cases vessel lumens and cavities within the plexus contain retinal pigment epithelial cells
(J:41411)
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• proliferating retinal pigment epithelial cells are found around some site of neovascularization
• some cells around the neovascularization sites contain large cavities
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pigmentation
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• proliferating retinal pigment epithelial cells are found around some site of neovascularization
• some cells around the neovascularization sites contain large cavities
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Analysis Tools