Adam15^tm1Dgen
Targeted Allele Detail

Summary

• Symbol: Adam15^tm1Dgen
• Name: ADAM metallopeptidase domain 15; targeted mutation 1, Deltagen
• MGI ID: MGI:3804711
• Gene: Adam15 Location: Chr3:89246947-89257589 bp, - strand Genetic Position: Chr3, 39.07 cM
• Alliance: Adam15^tm1Dgen page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:138010
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd
• Project Collection: Deltagen

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Intragenic deletion
• The sequence coding for amino acids A348 to L351 was removed by homologous recombination. (J:138010)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Adam15 Mutation: 36 strains or lines available

References

• Original: J:138010 Xie B, et al., An Adam15 amplification loop promotes vascular endothelial growth factor-induced ocular neovascularization. FASEB J. 2008 Aug;22(8):2775-83
• All: 1 reference(s)