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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Adam15tm1Dgen
targeted mutation 1, Deltagen
MGI:3804711
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Adam15tm1Dgen/Adam15tm1Dgen involves: 129P2/OlaHsd * C57BL/6 MGI:3806313
cx2
 		Adam15tm1Dgen/Adam15tm1Dgen
Tg(RHO-VEGFA)V-6Camp/0 		involves: 129P2/OlaHsd * C57BL/6 MGI:3806314


Genotype
MGI:3806313
hm1
Allelic
Composition		 Adam15tm1Dgen/Adam15tm1Dgen
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam15tm1Dgen mutation (0 available); any Adam15 mutation (37 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
decreased susceptibility to induced choroidal neovascularization ( J:138010 )
• reduced area of choroidal neovascularization at sites where Bruch's membrane was ruptured
abnormal induced retina neovascularization ( J:138010 )
• reduced retinal neovascularization following oxygen-induced ishemic retinopathy

vision/eye
decreased susceptibility to induced choroidal neovascularization ( J:138010 )
• reduced area of choroidal neovascularization at sites where Bruch's membrane was ruptured
abnormal induced retina neovascularization ( J:138010 )
• reduced retinal neovascularization following oxygen-induced ishemic retinopathy




Genotype
MGI:3806314
cx2
Allelic
Composition		 Adam15tm1Dgen/Adam15tm1Dgen
Tg(RHO-VEGFA)V-6Camp/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Adam15tm1Dgen mutation (0 available); any Adam15 mutation (37 available)
Tg(RHO-VEGFA)V-6Camp mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cardiovascular system
abnormal induced retina neovascularization ( J:138010 )
• reduction in subretinal neovascularization compared to transgenic littermates wild-type for Adam15

vision/eye
abnormal induced retina neovascularization ( J:138010 )
• reduction in subretinal neovascularization compared to transgenic littermates wild-type for Adam15




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory