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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1(tTA)Roos
targeted mutation 1, Raymond Roos
MGI:3806275
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Gt(ROSA)26Sortm1(tTA)Roos/?
Lhx3tm1(cre)Slp/Lhx3+
Tg(tetO-SOD1,-luc)1Roos/0 		involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:3806327
cn2
 		Gt(ROSA)26Sortm1(tTA)Roos/?
Lhx3tm1(cre)Slp/Lhx3+
Tg(tetO-SOD1*G93A,-luc)1Roos/0 		involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6 MGI:3806328
cn3
 		Col1a1tm1(tetO-SOX2)Mjm/Col1a1+
Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+
Lgr5tm1(cre/ERT2)Cle/Lgr5+ 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J MGI:5508638
cn4
 		Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+
Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+
Lgr5tm1(cre/ERT2)Cle/Lgr5+ 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J MGI:5508640
cx5
 		Gt(ROSA)26Sortm1(tTA)Roos/?
Tg(tetO/CMV-Dek,-luc)317Siwe/0 		involves: 129P2/OlaHsd * C57BL/6 * FVB/N MGI:6241414


Genotype
MGI:3806327
cn1
Allelic
Composition		 Gt(ROSA)26Sortm1(tTA)Roos/?
Lhx3tm1(cre)Slp/Lhx3+
Tg(tetO-SOD1,-luc)1Roos/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(tTA)Roos mutation (3 available); any Gt(ROSA)26Sor mutation (942 available)
Lhx3tm1(cre)Slp mutation (0 available); any Lhx3 mutation (25 available)
Tg(tetO-SOD1,-luc)1Roos mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:138761 )
N
• mice show no significant differences from triple mutants carrying the G93A version of SOD1, in the rotarod test when tested at 300 days and later

growth/size/body
growth/size/body region phenotype ( J:138761 )
N
• body weight is similar to non-transgenic controls




Genotype
MGI:3806328
cn2
Allelic
Composition		 Gt(ROSA)26Sortm1(tTA)Roos/?
Lhx3tm1(cre)Slp/Lhx3+
Tg(tetO-SOD1*G93A,-luc)1Roos/0
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(tTA)Roos mutation (3 available); any Gt(ROSA)26Sor mutation (942 available)
Lhx3tm1(cre)Slp mutation (0 available); any Lhx3 mutation (25 available)
Tg(tetO-SOD1*G93A,-luc)1Roos mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:138761 )
N
• mice show no significant differences relative to triple mutants carrying wild-type human SOD1, in the rotarod test when tested at 300 days and later
decreased motor neuron number ( J:138761 )
• significant decrease in number of spinal motor neurons (MNs) compared to wild-type and transgenic controls is observed at 450 days of age
abnormal ventral spinal root morphology ( J:138761 )
• significant decrease in number of axons in L5 anterior root at 450 days is observed compared to triple mutants expressing wild-type human SOD1

growth/size/body
decreased body weight ( J:138761 )
• after 300 days, mean body weight is reduced relative to wild-type or to triple mutants carrying the wild-type human SOD1 gene




Genotype
MGI:5508638
cn3
Allelic
Composition		 Col1a1tm1(tetO-SOX2)Mjm/Col1a1+
Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm1(tetO-SOX2)Mjm mutation (0 available); any Col1a1 mutation (160 available)
Gt(ROSA)26Sortm1(tTA)Roos mutation (3 available); any Gt(ROSA)26Sor mutation (942 available)
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
ectopic Paneth cells ( J:199754 )
• lyzsozyme+ Paneth cells in doxycycline-treated mice are not restricted to the base of the crypt unlike in control cells
abnormal ileum crypts of Lieberkuhn morphology ( J:199754 )
• expanded crypts in the ileum of doxycycline-treated mice
abnormal intestine physiology ( J:199754 )
• increased cell proliferation in the intestine of doxycycline-treated mice with an increase in intestinal stem Lgr5+ cells
• increased proliferation of intestinal stem cells in the intestine of doxycycline-treated mice
• expansion of intestinal stem cells is cell autonomous in doxycycline treated mice

cellular
increased cell proliferation ( J:199754 )
• in the intestine of doxycycline-treated mice with an increase in Lgr5+ intestinal stem cells
• increased proliferation of intestinal stem cells in the intestine of doxycycline-treated mice
• expansion of intestinal stem cells is cell autonomous in doxycycline treated mice

endocrine/exocrine glands
ectopic Paneth cells ( J:199754 )
• lyzsozyme+ Paneth cells in doxycycline-treated mice are not restricted to the base of the crypt unlike in control cells
abnormal ileum crypts of Lieberkuhn morphology ( J:199754 )
• expanded crypts in the ileum of doxycycline-treated mice




Genotype
MGI:5508640
cn4
Allelic
Composition		 Col1a1tm2(tetO-Pou5f1)Jae/Col1a1+
Gt(ROSA)26Sortm1(tTA)Roos/Gt(ROSA)26Sor+
Lgr5tm1(cre/ERT2)Cle/Lgr5+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA/2J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Col1a1tm2(tetO-Pou5f1)Jae mutation (1 available); any Col1a1 mutation (160 available)
Gt(ROSA)26Sortm1(tTA)Roos mutation (3 available); any Gt(ROSA)26Sor mutation (942 available)
Lgr5tm1(cre/ERT2)Cle mutation (1 available); any Lgr5 mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
abnormal small intestine crypts of Lieberkuhn morphology ( J:199754 )
• expanded crypts in the ileum of doxycycline-treated mice
abnormal intestine physiology ( J:199754 )
• increased cell proliferation in the intestine of doxycycline-treated mice without an increase in Lgr5+ cells

cellular
increased cell proliferation ( J:199754 )
• in the intestine of doxycycline-treated mice without an increase in Lgr5+ cells

endocrine/exocrine glands
abnormal small intestine crypts of Lieberkuhn morphology ( J:199754 )
• expanded crypts in the ileum of doxycycline-treated mice




Genotype
MGI:6241414
cx5
Allelic
Composition		 Gt(ROSA)26Sortm1(tTA)Roos/?
Tg(tetO/CMV-Dek,-luc)317Siwe/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(tTA)Roos mutation (3 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(tetO/CMV-Dek,-luc)317Siwe mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:261249 )
• no overt phenotypes observed




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory