Tg(tetO/CMV-Dek,-luc)317Siwe
Transgene Detail

Summary

• Symbol: Tg(tetO/CMV-Dek,-luc)317Siwe
• Name: transgene insertion 317, Susanne Wells
• MGI ID: MGI:6200913
• Synonyms: Bi-L-Dek
• Transgene: Tg(tetO/CMV-Dek,-luc)317Siwe Location: unknown
• Alliance: Tg(tetO/CMV-Dek,-luc)317Siwe page

Transgene origin

• Strain of Origin: FVB/N

Transgene description

• Transgene Type: Transgenic (Inducible, Inserted expressed sequence, Reporter)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Tg(tetO/CMV-Dek,-luc)317Siwe expresses 1 gene
  Transgene expresses:
  

  Organism	Expressed Gene	Note
  mouse	Dek (MGI:1926209)	inducible, bidirectional promoter with luciferase

• Mutation details: The transgene is designed with a bidirectional tetracycline operator (tetO; also called tetracycline-responsive element (TRE, TetRE) or tet-operator), Bi-L-Tet, located between two cytomegalovirus (CMV) minimal promoters in the opposite orientation. One CMV promoter drives expression of the murine DEK oncogene (DNA binding) gene (Dek) followed by a polyA signal, while the other CMV reporter drives expression of a luciferase (luc) reporter followed by a simian virus 40 (SV40) polyadenylation (polyA) signal. (J:261249)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available

References

• Original: J:261249 Matrka MC, et al., Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence. PLoS Genet. 2018 Mar;14(3):e1007227
• All: 1 reference(s)