All Phenotypes Vsig4<tm1Gne> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Vsig4^tm1Gne
targeted mutation 1, Genentech
MGI:3806036

Summary

7 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Vsig4^tm1Gne/Vsig4^tm1Gne	C57BL/6-Vsig4^tm1Gne	MGI:6384864
hm2	Vsig4^tm1Gne/Vsig4^tm1Gne	involves: C57BL/6N	MGI:3806097
cn3	Cr1l^tm1.1Song/Cr1l^tm1.1Song Vsig4^tm1Gne/Vsig4^tm1Gne Tg(Cd4-cre)1Cwi/0	involves: 129S6/SvEvTac * C57BL/6N * DBA/2 * SJL	MGI:3838226
cx4	Il1r1^tm1Imx/Il1r1^tm1Imx Vsig4^tm1Gne/Vsig4^tm1Gne	B6.Cg-Il1r1^tm1Imx Vsig4^tm1Gne	MGI:6384866
cx5	Nlrp3^tm2Hhf/Nlrp3^tm2Hhf Vsig4^tm1Gne/Vsig4^tm1Gne	B6.Cg-Nlrp3^tm2Hhf Vsig4^tm1Gne	MGI:6384868
cx6	C3^tm1Hrc/C3^tm1Hrc Cd55^tm1Song/Cd55^tm1Song Cr1l^tm1Hmo/Cr1l^tm1Hmo Vsig4^tm1Gne/Vsig4^tm1Gne	involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N	MGI:3806101
cx7	C3^tm1Hrc/C3^tm1Hrc Vsig4^tm1Gne/Vsig4^tm1Gne	involves: 129/Sv * C57BL/6N	MGI:3806098

Allelic Composition	Vsig4^tm1Gne/Vsig4^tm1Gne
Genetic Background	C57BL/6-Vsig4^tm1Gne

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vsig4^tm1Gne mutation (0 available); any Vsig4 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to induced colitis ( J:281762 )

• DSS-treated mice exhibit increased survival with reduced weight loss, colon degeneration, loss of epithelium barrier function, and increased cell proliferation in the colon compared with wild-type mice

increased T-helper 1 cell number ( J:281762 )

• in MOG35-55 treated mice

increased T-helper 17 cell number ( J:281762 )

• in MOG35-55 treated mice

abnormal macrophage physiology ( J:281762 )

• enhanced caspase-1-dependent induced pyroptosis peritoneal exudate macrophages

increased circulating interleukin-1 beta level ( J:281762 )

• in MOG35-55 or DSS-treated mice

increased interleukin-1 beta secretion ( J:281762 )

• from peritoneal exudate macrophages stimulated with LPS and nigericin, LPS and ATP, LPS and silica, or dsDNA treatment

• from macrophages of MOG35-55 treated mice

increased susceptibility to experimental autoimmune encephalomyelitis ( J:281762 )

• MOG35-55 treated mice exhibit increased EAE clinical score, increased leukocyte spinal cord infiltration, increased TH1 and TH17 cells in the spinal cord and spleen, and increased IL-beta expression form macrophages compared with wild-type mice

digestive/alimentary system

abnormal enterocyte proliferation ( J:281762 )

• DSS-treated mice exhibit increased cell proliferation in the colon compared with wild-type mice

decreased susceptibility to induced colitis ( J:281762 )

homeostasis/metabolism

increased circulating interleukin-1 beta level ( J:281762 )

• in MOG35-55 or DSS-treated mice

hematopoietic system

increased T-helper 1 cell number ( J:281762 )

• in MOG35-55 treated mice

increased T-helper 17 cell number ( J:281762 )

• in MOG35-55 treated mice

abnormal macrophage physiology ( J:281762 )

• enhanced caspase-1-dependent induced pyroptosis peritoneal exudate macrophages

cellular

abnormal enterocyte proliferation ( J:281762 )

• DSS-treated mice exhibit increased cell proliferation in the colon compared with wild-type mice

Allelic Composition	Vsig4^tm1Gne/Vsig4^tm1Gne
Genetic Background	involves: C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Vsig4^tm1Gne mutation (0 available); any Vsig4 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:138691 )

• following infection with Listeria monocytogenes, mice exhibit increased mortality compared to similarly treated wild-type mice

immune system

increased susceptibility to bacterial infection ( J:138691 )

• following infection with Listeria monocytogenes, mice exhibit increased bacterial counts in the blood, spleen and lungs, increased serum cytokine levels, reduced splenocyte numbers by day 6 of infection, reduced bacterial clearance and increased mortality compared to similarly treated wild-type mice

• following infection with Staphylococcus aureus, mice exhibit increased blood and bacterial counts compared to in similarly treated wild-type mice

Allelic Composition	Cr1l^tm1.1Song/Cr1l^tm1.1Song Vsig4^tm1Gne/Vsig4^tm1Gne Tg(Cd4-cre)1Cwi/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6N * DBA/2 * SJL

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cr1l^tm1.1Song mutation (0 available); any Cr1l mutation (30 available)
Tg(Cd4-cre)1Cwi mutation (10 available)
Vsig4^tm1Gne mutation (0 available); any Vsig4 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased lymphocyte cell number ( J:146538 )

• mice exhibit peripheral T cell lymphopenia

immune system

decreased lymphocyte cell number ( J:146538 )

• mice exhibit peripheral T cell lymphopenia

Allelic Composition	Il1r1^tm1Imx/Il1r1^tm1Imx Vsig4^tm1Gne/Vsig4^tm1Gne
Genetic Background	B6.Cg-Il1r1^tm1Imx Vsig4^tm1Gne

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il1r1^tm1Imx mutation (4 available); any Il1r1 mutation (39 available)
Vsig4^tm1Gne mutation (0 available); any Vsig4 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

increased susceptibility to induced colitis ( J:281762 )

• DSS-treated mice exhibit more severe colitis compared with wild-type mice and Vsig4^tm1Gne homozygotes

decreased T helper 1 cell number ( J:281762 )

• in MOG35-55 treated mice

decreased T-helper 17 cell number ( J:281762 )

• in MOG35-55 treated mice

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:281762 )

• MOG35-55 treated mice exhibit delayed onset and reduced clinical score, reduced leukocyte spinal cord infiltration, and decreased TH1 and TH17 cells in the spinal cord and spleen compared with wild-type mice and Vsig4^tm1Gne homozygotes

digestive/alimentary system

increased susceptibility to induced colitis ( J:281762 )

• DSS-treated mice exhibit more severe colitis compared with wild-type mice and Vsig4^tm1Gne homozygotes

hematopoietic system

decreased T helper 1 cell number ( J:281762 )

• in MOG35-55 treated mice

decreased T-helper 17 cell number ( J:281762 )

• in MOG35-55 treated mice

Allelic Composition	Nlrp3^tm2Hhf/Nlrp3^tm2Hhf Vsig4^tm1Gne/Vsig4^tm1Gne
Genetic Background	B6.Cg-Nlrp3^tm2Hhf Vsig4^tm1Gne

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nlrp3^tm2Hhf mutation (1 available); any Nlrp3 mutation (61 available)
Vsig4^tm1Gne mutation (0 available); any Vsig4 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

decreased susceptibility to experimental autoimmune encephalomyelitis ( J:281762 )

• MOG35-55 treated mice exhibit reduced clinical score compared with Vsig4^tm1Gne homozygotes

Allelic Composition	C3^tm1Hrc/C3^tm1Hrc Cd55^tm1Song/Cd55^tm1Song Cr1l^tm1Hmo/Cr1l^tm1Hmo Vsig4^tm1Gne/Vsig4^tm1Gne
Genetic Background	involves: 129/Sv * 129S6/SvEvTac * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3^tm1Hrc mutation (2 available); any C3 mutation (102 available)
Cd55^tm1Song mutation (2 available); any Cd55 mutation (39 available)
Cr1l^tm1Hmo mutation (0 available); any Cr1l mutation (30 available)
Vsig4^tm1Gne mutation (0 available); any Vsig4 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal platelet physiology ( J:138410 )

• unlike in C3^tm1Hrc Cd55^tm1Song Cr1l^tm1Hmo homozygotes, platelet half-life is normal

homeostasis/metabolism

abnormal platelet physiology ( J:138410 )

• unlike in C3^tm1Hrc Cd55^tm1Song Cr1l^tm1Hmo homozygotes, platelet half-life is normal

Allelic Composition	C3^tm1Hrc/C3^tm1Hrc Vsig4^tm1Gne/Vsig4^tm1Gne
Genetic Background	involves: 129/Sv * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3^tm1Hrc mutation (2 available); any C3 mutation (102 available)
Vsig4^tm1Gne mutation (0 available); any Vsig4 mutation (9 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:138691 )

N	• following infection with Staphylococcus aureus, bacterial counts are normal

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