About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Wnt9btm1.2Amc
targeted mutation 1.2, Andrew P McMahon
MGI:3805020
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Wnt9btm1.1Amc/Wnt9btm1.2Amc
Tg(CAG-cre/Esr1*)5Amc/0 		involves: 129X1/SvJ * C57BL/6 * CBA MGI:5428000
cn2
 		Wnt9btm1.1Amc/Wnt9btm1.2Amc
Tg(Cdh16-cre)91Igr/0 		involves: 129X1/SvJ * ICR MGI:5427999
cn3
 		Ctnnb1tm1Mmt/Ctnnb1+
Wnt9btm1.1Amc/Wnt9btm1.2Amc
Tg(Cdh16-cre)91Igr/0 		involves: 129X1/SvJ * ICR MGI:5428001


Genotype
MGI:5428000
cn1
Allelic
Composition		 Wnt9btm1.1Amc/Wnt9btm1.2Amc
Tg(CAG-cre/Esr1*)5Amc/0
Genetic
Background		 involves: 129X1/SvJ * C57BL/6 * CBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(CAG-cre/Esr1*)5Amc mutation (11 available)
Wnt9btm1.1Amc mutation (0 available); any Wnt9b mutation (21 available)
Wnt9btm1.2Amc mutation (1 available); any Wnt9b mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:151498 )
• all mice treated with tamoxifen from E15.5 die by P90

renal/urinary system
kidney cyst ( J:151498 )
• in mice treated with tamoxifen from E15.5 to P10
• however, mice treated with tamoxifen after P10 do not develop cysts

growth/size/body
kidney cyst ( J:151498 )
• in mice treated with tamoxifen from E15.5 to P10
• however, mice treated with tamoxifen after P10 do not develop cysts




Genotype
MGI:5427999
cn2
Allelic
Composition		 Wnt9btm1.1Amc/Wnt9btm1.2Amc
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cdh16-cre)91Igr mutation (1 available)
Wnt9btm1.1Amc mutation (0 available); any Wnt9b mutation (21 available)
Wnt9btm1.2Amc mutation (1 available); any Wnt9b mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
premature death ( J:151498 )
• most mice die between P30 and P45 with no mice surviving past P60

renal/urinary system
kidney cyst ( J:151498 )
• delayed compared to in Wnt9btm1Amc homozygotes
• few cysts at P1
• prevalent by P10
• by P15, mice develop cysts in all nephrons of glomerulus, proximal tubule, loop of Henle and collecting duct
abnormal kidney collecting duct epithelium morphology ( J:151498 )
• collecting duct epithelial cells exhibit randomized elongation unlike in wild-type mice
abnormal renal tubule epithelium morphology ( J:151498 )
• at P5, epithelium cell divisions are not oriented within the plane of the epithelium unlike in control mice
• by P30, little normal epithelia remains

growth/size/body
kidney cyst ( J:151498 )
• delayed compared to in Wnt9btm1Amc homozygotes
• few cysts at P1
• prevalent by P10
• by P15, mice develop cysts in all nephrons of glomerulus, proximal tubule, loop of Henle and collecting duct
renal glomerulus cyst ( J:151498 )




Genotype
MGI:5428001
cn3
Allelic
Composition		 Ctnnb1tm1Mmt/Ctnnb1+
Wnt9btm1.1Amc/Wnt9btm1.2Amc
Tg(Cdh16-cre)91Igr/0
Genetic
Background		 involves: 129X1/SvJ * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ctnnb1tm1Mmt mutation (0 available); any Ctnnb1 mutation (51 available)
Tg(Cdh16-cre)91Igr mutation (1 available)
Wnt9btm1.1Amc mutation (0 available); any Wnt9b mutation (21 available)
Wnt9btm1.2Amc mutation (1 available); any Wnt9b mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
kidney cyst ( J:151498 )
• cystic index at P1 is increased compared to in Wnt9btm1.1Amc/Wnt9btm1.2Amc Tg(Cdh16-cre)91Igr mice

growth/size/body
kidney cyst ( J:151498 )
• cystic index at P1 is increased compared to in Wnt9btm1.1Amc/Wnt9btm1.2Amc Tg(Cdh16-cre)91Igr mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory