About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Irs1tm2Tka
targeted mutation 2, Takashi Kadowaki
MGI:3803974
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Irs1tm2Tka/Irs1tm2Tka
Irs2tm2Tka/Irs2tm2Tka
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA MGI:3805348
cn2
 		Irs1tm2Tka/Irs1tm2Tka
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+ 		involves: 129P2/OlaHsd * C57BL/6 * DBA MGI:3805350


Genotype
MGI:3805348
cn1
Allelic
Composition		 Irs1tm2Tka/Irs1tm2Tka
Irs2tm2Tka/Irs2tm2Tka
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129P2/OlaHsd * 129S4/SvJae * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1tm2Tka mutation (0 available); any Irs1 mutation (55 available)
Irs2tm2Tka mutation (0 available); any Irs2 mutation (39 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
insulin resistance ( J:137846 )
• under fasting and refeeding conditions

immune system
increased susceptibility to autoimmune diabetes ( J:137846 )
• mice develop diabetes
• however, over-expression of a dominant negative Foxo1 by adenoviral transfection improves diabetes




Genotype
MGI:3805350
cn2
Allelic
Composition		 Irs1tm2Tka/Irs1tm2Tka
Speer6-ps1Tg(Alb-cre)21Mgn/Speer6-ps1+
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6 * DBA
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Irs1tm2Tka mutation (0 available); any Irs1 mutation (55 available)
Speer6-ps1Tg(Alb-cre)21Mgn mutation (6 available); any Speer6-ps1 mutation (4 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
homeostasis/metabolism phenotype ( J:137846 )
N
• mice exhibit normal hepatic triglyceride content, serum aspartate aminotransferase and alanine aminotransferase indicating a lack of hepatic injury
increased circulating insulin level ( J:137846 )
• mice exhibit higher serum insulin levels 4 and 6 hours after the start of refeeding unlike wild-type mice
insulin resistance ( J:137846 )
• mice exhibit insulin resistance under refeeding conditions
• however, mice do not exhibit insulin resistance under fasting conditions




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory