Phenotypes associated with this allele
neoplasm
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• mice exhibit similar tumorigenesis as Atmintm1.1Jhh/Atmintm1.1Jhh Tg(Fcer2a-cre)5Mbu mice
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Atmintm1.1Jhh mutation
(2 available);
any
Atmin mutation
(38 available)
Tg(Fcer2a-cre)5Mbu mutation
(4 available)
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hematopoietic system
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N |
• mice exhibit normal B cell numbers in the spleen and antigen-specific IgG1-switched antibodies
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neoplasm
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N |
• mice repeatedly immunized with sheep red blood cells do not exhibit an increase in tumor-related death
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Hdac1tm1.1Pmt mutation
(0 available);
any
Hdac1 mutation
(36 available)
Hdac2tm1.1Pmt mutation
(0 available);
any
Hdac2 mutation
(38 available)
Tg(Fcer2a-cre)5Mbu mutation
(4 available)
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immune system
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• massive induction of apoptosis is detected when cells are cultured with LPS and IL4 or anti-IgM Fab
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• fail to proliferate in response to LPS and IL4 or anti-IgM Fab fragment stimulation
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hematopoietic system
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• massive induction of apoptosis is detected when cells are cultured with LPS and IL4 or anti-IgM Fab
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• fail to proliferate in response to LPS and IL4 or anti-IgM Fab fragment stimulation
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cellular
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• massive induction of apoptosis is detected when cells are cultured with LPS and IL4 or anti-IgM Fab
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• fail to proliferate in response to LPS and IL4 or anti-IgM Fab fragment stimulation
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm1.2Mbu mutation
(0 available);
any
Tcf3 mutation
(39 available)
Tcf3tm1Mbu mutation
(1 available);
any
Tcf3 mutation
(39 available)
Tg(Fcer2a-cre)5Mbu mutation
(4 available)
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immune system
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N |
• despite reduced B cell numbers, class switching, NP-specific production of IgG1, IgG2a and IgG3, B cell proliferation, memory B cells and plasma B cells following stimulation are normal following immunization
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• splenic B cell numbers are minimally reduced compared to in wild-type mice
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• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal
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• at 4 and 8 days after immunization germinal center B cell numbers are 3- to 5-fold lower tan in wild-type or heterozygous mice
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hematopoietic system
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• splenic B cell numbers are minimally reduced compared to in wild-type mice
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• at 4 and 8 days after immunization germinal center B cell numbers are 3- to 5-fold lower tan in wild-type or heterozygous mice
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• 8 days following immunization, PNA+ germinal center number and size are reduced compared to in wild-type or heterozygous mice
• however, stimulated germinal B cell proliferation is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nfatc1tm1Rao mutation
(0 available);
any
Nfatc1 mutation
(47 available)
Tg(Fcer2a-cre)5Mbu mutation
(4 available)
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immune system
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• stimulated B cells exhibit reduced ability to induced T cell proliferation
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• alpha-IgM-mediated
• however, LPS-stimulated B cell proliferation is normal
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• to IgG3 induced by T cell-independent type II antigens
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• after immunization with NP-KLH
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• 10-fold after immunization with NP-Ficoll
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• after immunization with NP-Ficoll
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• in unstimulated B cells
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• from LPS-stimulated B cells
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• from stimulated B cells
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hematopoietic system
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• stimulated B cells exhibit reduced ability to induced T cell proliferation
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• alpha-IgM-mediated
• however, LPS-stimulated B cell proliferation is normal
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• to IgG3 induced by T cell-independent type II antigens
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• after immunization with NP-KLH
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• 10-fold after immunization with NP-Ficoll
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• after immunization with NP-Ficoll
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• in unstimulated B cells
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cellular
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• alpha-IgM-mediated
• however, LPS-stimulated B cell proliferation is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rtcbtm1c(KOMP)Wtsi mutation
(0 available);
any
Rtcb mutation
(25 available)
Tg(Fcer2a-cre)5Mbu mutation
(4 available)
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immune system
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• slight decrease in the percentage of CD138+ CD22- plasmablasts in cells stimulated with LPS in vitro
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• plasmablasts have disorganized and less dense ER structures
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• impaired ability of plasma cells to secrete immunoglobins
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• in culture supernatants of pre-plasmablasts and plasmablasts
• however, the number of plasmablasts secreting IgM is similar to control cultures
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hematopoietic system
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• slight decrease in the percentage of CD138+ CD22- plasmablasts in cells stimulated with LPS in vitro
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• plasmablasts have disorganized and less dense ER structures
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• impaired ability of plasma cells to secrete immunoglobins
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• in culture supernatants of pre-plasmablasts and plasmablasts
• however, the number of plasmablasts secreting IgM is similar to control cultures
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Analysis Tools
